. 2023 Feb 4;13:2066. doi: 10.1038/s41598-023-29227-2

Table 2.

Effect of COCs on symptomatic evaluation at baseline and at 12 and 24 months of follow-up in endometriosis and adenomyosis patients.

Variables	Baseline^a N = 64	12-month follow-up N = 63	24-month follow-up N = 53	p-value
Severe dysmenorrea*	52 (82.5%)^a	4(6.3%)^b	0 (0%)^c	^a-bp < 0.001;^b-c NS
Severe dysmenorrea*	52 (82.5%)^a	4(6.3%)^b	0 (0%)^c	^a-cp < 0.001
Severe non-menstrual pelvic pain*	20 (31.7%)^a	0 (0%)^b	0 (0%)^c	^a-b p < 0.001;^b-c NS
Severe non-menstrual pelvic pain*	20 (31.7%)^a	0 (0%)^b	0 (0%)^c	^a-cp < 0.001
Dysmenorrhea**	8.05 ± 1.61^a	3.76 ± 2.19^b	1.51 ± 1.60^c	^{a-b, b-c, a-c}p < 0.001
Non-menstrual pelvic pain**	5.95 ± 1.52^a	2.08 ± 1.65^b	0.79 ± 1.17^c	^{a-b, b-c, a-c} p < 0.001
Dyspareunia**	3.70 ± 3.59^a	0.81 ± 1.85^b	0.70 ± 1.65^c	^{a-b, a-c}p < 0.001
Dyspareunia**	3.70 ± 3.59^a	0.81 ± 1.85^b	0.70 ± 1.65^c	^b-cNS
Dyschezia**	1.98 ± 3.41^a	0.44 ± 1.39^b	0.45 ± 1.42^c	^{a-b, a-c}p < 0.001
Dyschezia**	1.98 ± 3.41^a	0.44 ± 1.39^b	0.45 ± 1.42^c	^b-cNS
Dysuria**	0.43 ± 1.68^a	0.11 ± 0.63^b	0.13 ± 0.68^c	^{a-b, b-c, a-c}p = NS

Results expressed as number and percentage or mean ± standard deviation.

NS not significant.

*Numerical Rating Scale (NRS) ≥ 7.

**Mean NRS.