Table 4.

Associations of longitudinal changes in high attenuation areas with mortality and interstitial lung disease

Model	No. Participants	Total Person-years	Events	Event Rate per 10,000 Person-Years (95% CI)	Rate Ratio per 1% Increment in HAAs per year (95% CI)	P-value
Overall mortality	4,517	74,415	827	111.1 (103.8 to 118.9)	1.07 (1.02 to 1.12)	<0.001
Interstitial lung disease	4,443	53,173	29	5.5 (3.7 to 7.7)	1.34 (1.20 to 1.50)	<0.001

Abbreviations: CI=confidence intervals; HAAs=high attenuation areas

Models adjusted for sex, self-reported race/ethnicity, baseline age, smoking status, cigarette pack-years, height, weight, systolic and diastolic blood pressures, total cholesterol, high-density lipoprotein cholesterol, diabetes history, cancer history, coronary artery calcium score, percent emphysema, and total intentional exercise (met-min/week).

Interstitial lung disease events defined as a hospitalization or death related to interstitial lung disease using ICD-9 ICD-10 codes (ICD-9 codes 495.XX, 515.XX, or 516.XX and ICD-10 codes J60.X-J64.X, J67.X, or J84.X)