Table 3:
Macular characteristics of eyes with and without extramacular drusen
| Features within the macula | Extramacular drusen | P value | |
|---|---|---|---|
| Absent | Present | ||
| N (Col%) | N (Col%) | ||
| Total | 544 (100.0%) | 3624 (100.0%) | |
| Max drusen size with macular grid | 3 (0.6%) | 1 (0.0%) | |
| Absent/Questionable | P < 0.0001 | ||
| Definite, <63 um | 1 (0.2%) | 14 (0.4%) | |
| Definite, <125 um | 23 (4.2%) | 117 (3.2%) | |
| Definite, <250 um | 283 (52.0%) | 1538 (42.4%) | |
| Definite, >=250 um | 234 (43.0%) | 1954 (53.9%) | |
| Increased pigment within macular grid | |||
| Absent/Questionable | 188 (34.5%) | 1178 (32.5%) | P=0.64 |
| Definite, <C2 (0.07mm2) | 210 (38.6%) | 1445 (39.9%) | |
| Definite, >=C2 | 146 (26.8%) | 1001 (27.6%) | |
| Decreased pigment within macular grid | |||
| Absent/Questionable | 407 (74.8%) | 2632 (72.6%) | P=0.19 |
| Definite, <I2 (0.15mm2) | 48 (8.8%) | 380 (10.5%) | |
| Definite, <1/2 DA (1.27mm2) | 72 (13.2%) | 440 (12.1%) | |
| Definite, >=1/2 DA | 17 (3.1%) | 172 (4.7%) | |
| Drusen area within center subfield | |||
| Absent/Questionable | 30 (5.5%) | 198 (5.5%) | P = 0.09 |
| Definite, <C1 (0.02mm2) | 22 (4.0%) | 158 (4.4%) | |
| Definite, <C2 (0.07mm2) | 65 (11.9%) | 485 (13.4%) | |
| Definite, <I2 (0.15mm2) | 105 (19.3%) | 651 (18.0%) | |
| Definite, <O2 (0.50mm2) | 218 (40.1%) | 1263 (34.9%) | |
| Definite, <1/2 DA (1.27mm2) | 104 (19.1%) | 867 (23.9%) | |
| Cannot grade | 0 (0.0%) | 2 (0.1%) | |
| Drusen area within macular grid | |||
| Absent, Questionable, | 4 (0.7%) | 9 (0.2%) | P<0.0001 |
| Definite, <C1 (0.02mm2) | 2 (0.4%) | 5 (0.1%) | |
| Definite, <C2 (0.07mm2) | 9 (1.7%) | 47 (1.3%) | |
| Definite, <I2 (0.15mm2) | 20 (3.7%) | 85 (2.3%) | |
| Definite, <O2 (0.50mm2) | 65 (11.9%) | 281 (7.8%) | |
| Definite, <1/2 DA (1.27mm2) | 120 (22.1%) | 543 (15.0%) | |
| Definite, <1 DA (2.54mm2) | 126 (23.2%) | 900 (24.8%) | |
| Definite, >=1 DA | 198 (36.4%) | 1754 (48.4%) | |
| Baseline AREDS severity scale | |||
| 1 – 5 | 123 (22.6%) | 590 (16.3%) | P<0.0001 |
| 6 | 161 (29.6%) | 887 (24.5%) | |
| 7 | 206 (37.9%) | 1643 (45.3%) | |
| 8 | 54 (9.9%) | 504 (13.9%) | |
AREDS= Age-Related Eye Disease Study