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. Author manuscript; available in PMC: 2023 Feb 5.
Published in final edited form as: Adv Exp Med Biol. 2021;1349:275–301. doi: 10.1007/978-981-16-4254-8_13

Fig. 13.3.

Fig. 13.3

CICR in VSMCs. In response to stimuli such as FasL and ET-1, CD38 converts NADP+ to NAADP which may activate TRPML1 channel. Ca2+ released through the TRPML1 channel drives lysosome trafficking toward the SR, where aggregated lysosomes further release Ca2+ to activate RyRs to produce large Ca2+ release from the SR, leading to the contraction of myofilament