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. 2023 Feb 4;20:25. doi: 10.1186/s12974-023-02712-1

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Endothelial Tlr4 depletion rescue the retina from LPS-induced visual dysfunction. Representative waveforms at baseline (A, C, E) and after the LPS challenge (B, D, F) under scotopic conditions in C57BL/6J, Tek^Cre−negTlr4^loxP/loxP and Tek^Cre−posTlr4^loxP/loxP mice, respectively. Comparison of a- (G, I, K) and b-wave amplitudes (H, J, L) between baseline and LPS in C57BL/6J, Tek^Cre−negTlr4^loxP/loxP and Tek^Cre−posTlr4^loxP/loxP mice, respectively. Reduced mean a- and b-wave amplitudes were recorded in C57BL/6J and Tek^Cre−negTlr4^loxP/loxP mice after the LPS challenge. In Tek^Cre−posTlr4^loxP/loxP mice, mean a- and b-wave amplitudes after the LPS challenge were comparable to baseline levels. The data were analyzed with repeated measures 2-way ANOVA followed by Sidak’s post hoc analysis (n = 4–5 mice per genotype, one eye per mouse; *p < 0.05, **p < 0.01, ***p < 0.001)