TABLE 4.
Structural genes of ATP synthase subunits
| Genea | Proteinb | Mutation | % Petite productionc | Referenced |
|---|---|---|---|---|
| OLI2, PHO1, ATP6 (mt) | Atp6 (F0) | Point | 20–80 | 97 |
| OLI1, PHO2, ATP9 (mt) | Atp9 (F0) | Point | 35–49 | 54 |
| AAP1, ATP8 (mt) | Atp8 (F0) | Point | 50–70 | 214 |
| ATP4 (n) | b (F0) | Disruption | 70 | 229 |
| ATP5 (n) | OSCP (F0) | Disruption | 40–80 | 242 |
| ATP7 (n) | d (F0) | Deletion | High | 220 |
| ATP14 (n) | h (F0) | Deletion | 90 | 8 |
| ATP17 (n) | f (F0) | Disruption | 60 | 285 |
| ATP18 (n) | j (F0 | Disruption | High | 7e |
| ATP1 (n) | α (F1) | Uncharacterized | 1 | 306 |
| Deletion | <1 | 170 | ||
| ATP2 (n) | β (F1) | Uncharacterized | 1 | 306 |
| Deletion | <1 | 170 | ||
| ATP3 (n) | γ (F1) | Disruption | 20 | 228 |
| Deletion | 100 | 170f | ||
| ATP16 (n) | δ (F1) | Deletion | Near 100 | 106 |
| Deletion | 100 | 170 | ||
| ATP15 (n) | ɛ (F1) | Deletion | 25–50 | 119 |
| Deletion | 60 | 170 |
The genes are carried by either the mitrochondrial (mt) or the nuclear (n) genomes.
The proteins are parts of either the proton channel membrane (F0) or the catalytic (F1) sectors of ATP synthase.
The methods used by the authors do not discriminate between rho− and rho0 petites. The values must be interpreted with caution since the basal level of petite production observed in the reference strains was not reported except in the study performed by Lai-Zhang et al. (170): here the wild-type reference strain produces 9% petites.
References are those reporting about petite production. See the text for other relevant references.
Vaillier et al. (309) reported contradictory data concerning ATP18.
The slight discrepancy between these data might be explained, as suggested by Lai-Zhang et al. (170), by the differences in how the null mutants were constructed, giving rise to a complete or partial deletion.