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. 2022 Nov 13;114(2):654–664. doi: 10.1111/cas.15617

FIGURE 1.

FIGURE 1

TAS2940 is a covalent human epidermal growth factor receptor type 2 (HER2)/epidermal growth factor receptor (EGFR) inhibitor containing HER2/EGFR exon 20 insertions. (A) Chemical structure of TAS2940. (B) Liquid chromatography‐mass spectrometry analysis of the recombinant human HER2 cytoplasmic domain (HER2cyt). (C) MSE spectrum confirmation for protease‐digested recombinant human HER2 peptide (LLGICLTSTVQLVTQLMPYGCLLDHVR) with TAS2940. (D) Kinase inhibitory activity of TAS2940 and approved or investigational HER2/EGFR inhibitors on HER2. (E) Kinase inhibitory activity of TAS2940 and approved or investigational HER2/EGFR inhibitors on EGFR. The mean ± SD of the IC50 value of each compound was calculated from three independent experiments. (F) Kinome inhibition plot of TAS2940 (left) and poziotinib (right).