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. 2022 Nov 1;114(2):436–448. doi: 10.1111/cas.15607

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© 2022 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Gene Set Enrichment Analysis (GSEA) of BACH1‐knockdown renal cell carcinoma cells. (A) Normalized enrichment scores of the top 20 downregulated pathways of hallmark gene sets enriched in BACH1‐knockdown 786‐O cells. *p < 0.05 and ***p < 0.001, compared with control siRNA‐introduced control. (B) Enrichment pattern of hallmark inflammatory response‐related, (C) epithelial–mesenchymal transition‐related, (D) mTORC1 signaling‐related, and (E) angiogenesis‐related gene sets determined by GSEA comparing BACH1‐knockdown (siBACH1) and control cells. q values are also indicated.