TABLE 3.
Toxicities and clinical outcomes in patients with leukemia treated with myeloablative conditioning with 3‐day total marrow and lymphoid irradiation
| Case | Dose | Neutrophil engraftment (days) | Toxicities | aGVHD max grade (organ, stage) | cGVHD | Relapse (days after HSCT) | Outcome | Follow‐up (days) | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Bearman grade ≤2 (grade) | CTCAE Grade ≤2 (grade) | Grade ≥3 | ||||||||
| 1 | 14 | 21 | Renal (2) Oral mucositis (2) | Nausea (2) | — | II (GI 1) | Mouth (mild) Skin (mild) | — | Alive | 1037 |
| 2 | 14 | 19 |
Renal (2) Oral mucositis (2) |
Nausea (2) Sinusitis (2) Otitis media (2) |
— | — | — | — | Alive | 932 |
| 3 | 14 | 18 | Renal (2) |
Nausea (2) Skin infection (2) Arthritis (2) |
— | — | — | Yes (day 176) | Dead | 306 |
| 4 | 16 | 19 | Oral mucositis (2) | Abdominal pain (1) | — | IV (skin 4) |
Mouth (mild) Eye (mild) |
— | Alive | 617 |
| 5 | 16 | 16 | GI (1) | Nausea (2) | — | IV (skin 4) | — | Yes (day 298) | Alive | 601 |
| 6 | 16 | 19 | GI (1) | Nausea (1) | — | — | — | Yes (day 90) | Alive | 575 |
| 7 | 18 | 25 | Oral mucositis (2) | Otitis media (2) | — | I (skin 1) | — | — | Alive | 318 |
| 8 | 18 | 14 | GI (1) | Nausea (2) | — | II (skin 1, GI 1) | — | — | Alive | 304 |
| 9 | 18 | 23 |
Oral mucositis (2) GI (1) |
Anal pain (2) | — | I (skin 1) | — | — | Alive | 253 |
Abbreviations: aGVHD, acute graft‐versus‐host disease; cGVHD, chronic graft‐versus‐host disease; CTCAE, Common Terminology Criteria for Adverse Events; GI, gastrointestinal; HSCT, hematopoietic stem cell transplantation; max, maximum.