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. Author manuscript; available in PMC: 2023 Feb 6.
Published in final edited form as: Exp Neurol. 2022 Jun 9;355:114141. doi: 10.1016/j.expneurol.2022.114141

Figure 1. Characterization of cKO (PV-Kcnq2fl/fl) mice.

Figure 1.

(A) Representative WT (PV-Kcnq2+/+) and littermate cKO mice at P30. (B) No difference in relative growth curves across genotypes (n = 18, 10). (C) Survival rate of WT (n = 163) and cKO mice (n=101, p > 0.05, Gehan-Breslow test) as a function of postnatal day. (D) No difference between genotypes in EEG spectral power at frequencies between 2–150 Hz (n = 5, mean ± SEM, p > 0.05, Tukey’s multiple comparisons test). There was also no significant difference between groups in performance on the (E) Tail Suspension Test (n = 12 each, median±95% confidence intervals, p = 0.887, Mann-Whitney U-test), the (F) Heat Sensitivity Test (n = 11 each, p = 0.699), or the (G) Balance Beam Test (n = 9–10, p = 0.434)