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. Author manuscript; available in PMC: 2023 Feb 6.
Published in final edited form as: Exp Neurol. 2022 Jun 9;355:114141. doi: 10.1016/j.expneurol.2022.114141

Figure 2. Improved efficacy of RTG in preventing PTX- and KA-induced seizures in cKO mice.

Figure 2.

Percentage of (A) WT (*p = 0.059; n = 16, 16) and (B) cKO (**p = 0.003; n = 12, 14) mice remaining seizure free with or without RTG plotted against time after PTX injection (Gehan-Breslow test). WT and cKO are also compared (C) without RTG (**p = 0.002) and (D) with RTG (p = 0.214). Percentage of (E) WT (*p = 0.042; n = 21, 22) and (F) cKO (*p = 0.040; n = 18, 18) mice with or without RTG administration plotted against time after KA injection (Gehan-Breslow test). WT and cKO are also compared (G) without RTG (***p < 0.001) and (H) with RTG (p = 0.953). Considering only mice with seizures, seizure onset was significantly increased by RTG in cKO but not WT mice in both the (I) PTX and (J) KA models (**p < 0.01, Kruskal-Wallis test with Dunn’s post-hoc tests).