Figure 5.

Forest plots of metabolites association with markers of disease severity. Forest plots display the relative effect sizes and 95% CIs of significant metabolites and 6MWD, functional class, right atrial pressure, and Fick cardiac index. P values and effect sizes were derived from linear regression analysis for 6MWD, right atrial pressure, and cardiac index, and from logistic regression analysis for functional class. 6MWD = 6-minute walk distance; FAHFA = fatty acyl esters of hydroxy fatty acid; Eic = eicosanoid; IPAH = idiopathic pulmonary arterial hypertension; PGF_2α = prostaglandin F_2α; SSc-PAH = systemic sclerosis-associated pulmonary arterial hypertension; SSc-no PH = systemic sclerosis without associated pulmonary arterial hypertension.