Table 2.
Demographic Characteristics and Clinical Features of Patients With SSc-No PH and SSc-PAH (Cohort 3)
| Characteristic | SSc-no PH (n = 100) | SSc-PAH (n = 44) | PValue |
|---|---|---|---|
| Age, y | 53.35 ± 14.86 | 59.05 ± 11.31 | .025 |
| Female | 87 (87.0) | 38 (86.4) | .91 |
| Disease duration, y | 7.65 ± 6.62 | 11.69 ± 8.33 | .01 |
| BMI, kg/m2 | 27.44 ± 5.67 | 29.21 ± 7.22 | .123 |
| Immunosuppression therapy | 21 (21.0) | 8 (18.2) | .871 |
| WHO functional class | < .001 | ||
| I | 45 (71.4) | 5 (16.7) | |
| II | 17 (27.0) | 14 (46.7) | |
| III | 1 (1.6) | 10 (33.3) | |
| IV | 0 | 1 (3.3) | |
| FVC, % predicted | 87.82 ± 21.61 | 76.55 ± 19.72 | .009 |
| FEV1, % predicted | 85.60 ± 20.85 | 71.17 ± 19.47 | .001 |
| Dlco, % predicted | 66.63 ± 20.93 | 41.44 ± 20.62 | < .001 |
| RVSP, mm Hg | 27.97 ± 7.49 | 62.32 ± 22.78 | < .001 |
| mRAP, mm Hg | 3.17 ± 3.19 | 5.88 ± 4.69 | .18 |
| PAWP, mm Hg | 8.33 ± 3.61 | 10.12 ± 5.61 | .455 |
| mPAP, mm Hg | 23.29 ± 9.05 | 36.86 ± 13.94 | .017 |
| Cardiac index, L/min/m | 2.82 ± 0.48 | 2.82 ± 0.70 | .982 |
| PVR, Woods units | 3.2 ± 2.4 | 6.2 ± 5.4 | .195 |
Data are expressed as mean ± SD or No. (%). Dlco = diffusing capacity of the lung for carbon monoxide; mPAP = mean pulmonary artery pressure; mRAP = mean right atrial pressure; PAWP = pulmonary artery wedge pressure; PVR = pulmonary vascular resistance; RVSP = right ventricular systolic pressure; SSc-no PH = systemic sclerosis without associated pulmonary arterial hypertension; SSc-PAH = systemic sclerosis-associated pulmonary arterial hypertension.