Table 3.
Metabolites Distinguishing SSc-PAH From IPAH
| Metabolite | Pathway | Discovery |
Validation |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FC | OR | CI-L | CI-U | P Value | FDR | FC | OR | CI-L | CI-U | P Value | FDR | ||
| Lignoceric acid | Fatty acid metabolism | 1.3 | 1.4 | 1.2 | 1.6 | 7E-05 | 8E-05 | 1.2 | 1.5 | 1.1 | 2.0 | 5E-03 | 9E-03 |
| Nervonic acid | Fatty acid metabolism | 1.1 | 1.6 | 1.3 | 1.9 | 3E-07 | 9E-07 | 1.16 | 1.6 | 1.2 | 2.1 | 3E-03 | 7E-03 |
| FAHFA | Fatty acid metabolism | 1.3 | 1.6 | 1.4 | 2.0 | 9E-07 | 2E-06 | 1.3 | 1.6 | 1.1 | 2.5 | 2E-02 | 3E-02 |
| Nitrooleate | Fatty acid metabolism | 0.6 | 0.8 | 0.7 | 0.9 | 1E-04 | 1E-04 | 0.7 | 0.8 | 0.6 | 1.0 | 5E-02 | 5E-02 |
| 11-Testosterone | Steroid hormones metabolism | 0.8 | 0.7 | 0.6 | 0.8 | 3E-06 | 4E-06 | 0.7 | 0.5 | 0.4 | 0.7 | 2E-05 | 2E-04 |
| 17β estradiol | Steroid hormones metabolism | 2 | 1.5 | 1.3 | 1.7 | 1E-08 | 6E-08 | 1.8 | 1.7 | 1.3 | 2.1 | 2E-04 | 6E-04 |
| Novel eicosanoid | Arachidonic acid metabolism | 1.5 | 1.6 | 1.4 | 1.8 | 9E-09 | 6E-08 | 2.2 | 1.8 | 1.3 | 2.4 | 2E-04 | 6E-04 |
| PGF2α | Arachidonic acid metabolism | 1.3 | 1.6 | 1.3 | 1.9 | 2E-06 | 3E-06 | 1.3 | 1.4 | 1.1 | 1.9 | 9E-03 | 1E-02 |
| LTB4 | Arachidonic acid metabolism | 1.5 | 1.4 | 1.2 | 1.6 | 8E-06 | 9E-06 | 1.3 | 1.4 | 1.0 | 1.7 | 2E-02 | 3E-02 |
P values originated from multivariable regression analysis. ORs reflect multivariable regression analysis. Fold change (FC) reflects the mean average of the metabolite level in systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) over idiopathic pulmonary arterial hypertension (IPAH). CI-L = lower confidence interval; CI-U = upper confidence interval; FAHFA = fatty acyl esters of hydroxy fatty acid; FDR = false discovery rate; LTB4 = leukotriene B4; PGF2α = prostaglandin F2α.