Table 4.
Comparisons Between Metabolite Levels in SSc-PAH and SSc-no PH
| Metabolite | FC | OR | CI-L | CI-U | P Value | FDR |
|---|---|---|---|---|---|---|
| Lignoceric acid | 0.8 | 0.7 | 0.5 | 1.0 | 5E-02 | 0.05 |
| Nervonic acid | 1.2 | 2 | 1.3 | 3.0 | 2E-03 | 0.01 |
| FAHFA | 5 | 2.8 | 1.7 | 4.5 | 5E-05 | < 0.001 |
| 17β estradiol | 1.4 | 1.6 | 1.1 | 2.8 | 2E-02 | 0.03 |
| Novel eicosanoid | 1.3 | 1.9 | 1.2 | 2.9 | 4E-03 | 0.01 |
| PGF2α | 1.3 | 1.6 | 1.0 | 2.4 | 3E-02 | 0.05 |
| LTB4 | 0.6 | 0.7 | 0.5 | 1.0 | 5E-02 | 0.05 |
P values originated from multivariable logistic regression analysis. Fold change (FC) reflects the mean average of metabolite level in systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) over systemic sclerosis without associated pulmonary arterial hypertension (SSc-no PH). ORs originated from multivariable logistic regression analysis. CI-L = lower CI; CI-U = upper CI; FAHFA = fatty acyl esters of hydroxy fatty acid; FDR = false discovery rate; LTB4 = leukotriene B4; PGF2α = prostaglandin F2α.