Table 1.
Cohort Characteristics of Osteoporotic Fractures (MrOS) Based on Arousal-Related QTVi Quartiles
|
Variable |
All Subjects (N = 2,558) | QTVi < 0.42 (Q1-Q3) (n = 1,918) |
QTVi ≥ 0.42 (Q4) (n = 640) |
P Value |
|---|---|---|---|---|
| Age, y | 76.3 ± 5.5 | 76.2 ± 5.5 | 76.5 ± 5.6 | .256 |
| Race | ||||
| White | 2,336 (91.3) | 1,739 (90.7) | 597 (93.3) | .051 |
| Black | 79 (3.1) | 58 (3.0) | 21 (3.3) | .846 |
| Asian | 79 (3.1) | 71 (3.7) | 8 (1.2) | .003 |
| Other | 64 (2.5) | 50 (2.6) | 14 (2.2) | .658 |
| Body weight | ||||
| BMI, kg/m2 | 27.2 ± 3.8 | 27.1 ± 3.7 | 27.5 ± 4.1 | .019 |
| Overweight | 1,276 (49.9) | 957 (49.9) | 319 (49.8) | .982 |
| Obese | 525 (20.5) | 393 (20.5) | 132 (20.6) | .987 |
| Cardiac assessment | ||||
| Atrial fibrillation | 258 (10.1) | 160 (8.3) | 98 (15.3) | < .001 |
| SBP, mm Hg | 126.5 ± 17 | 126.4 ± 17 | 126.7 ± 17 | .730 |
| DBP, mm Hg | 67.5 ± 9.4 | 67.4 ± 9.4 | 67.7 ± 9.3 | .499 |
| Lifestyle | ||||
| Smoking | ||||
| Never | 1,019 (40) | 764 (39.8) | 255 (39.8) | .966 |
| Past | 1,489 (58.2) | 1,116 (58.2) | 373 (58.3) | .996 |
| Current | 50 (1.9) | 38 (2.0) | 12 (1.9) | .997 |
| Current alcohol consumers | 1,687 (66) | 1,193 (62.2) | 493 (77.0) | < .001 |
| PASE score | 146.4 ± 71.2 | 148.5 ± 71.6 | 140.2 ± 69.8 | .011 |
| Medical history | ||||
| Stroke | 87 (3.4) | 63 (3.3) | 24 (3.8) | .663 |
| CAD/MI | 418 (16.3) | 281 (14.7) | 137 (21.4) | < .001 |
| CHF | 151 (5.9) | 96 (5.0) | 55 (8.6) | .001 |
| TIA | 233 (9.1) | 163 (8.5) | 70 (10.9) | .075 |
| Asthma | 202 (7.9) | 151 (7.9) | 51 (8.0) | .994 |
| COPD | 136 (5.3) | 100 (5.2) | 36 (5.6) | .764 |
| HTN | 1271(49.7) | 938 (48.9) | 333 (52) | .186 |
| Diabetes | 328 (12.8) | 237 (12.4) | 91 (14.2) | .249 |
| Parkinson disease | 27 (1.1) | 18 (0.9) | 9 (1.4) | .436 |
| Overnight polysomnography | ||||
| AHI, h–1 | 19.9 ± 12.8 | 19.9 ± 13 | 20.0 ± 12.4 | .956 |
| AI, h–1 | 25.1 ± 12.5 | 25.0 ± 12.4 | 25.4 ± 12.7 | .456 |
| AB, % | 6.6 ± 3.2 | 6.6 ± 3.4 | 6.6 ± 3.2 | .728 |
| PLMI, h–1 | 10.6 ± 10 | 10.5 ± 9.6 | 10.9 ± 11.1 | .356 |
| MRR, min–1 | 14.8 ± 1.9 | 14.7 ± 1.8 | 14.9 ± 1.7 | .049 |
| T90, min | 14.2 ± 32.6 | 13.6 ± 31.5 | 15.9 ± 35.8 | .118 |
Data are presented as mean ± SD or No. (%). Boldface indicates a P value with statistical significance. AB = arousal burden; AHI = apnea/hypopnea index; AI = arousal index; CAD = coronary artery disease; CHF = congestive heart failure; DBP = diastolic BP; HTN = hypertension; MI = myocardial infarction; MrOS = Osteoporotic Fractures in Men; MRR = mean respiratory rate; PASE = Physical Activity Scale for Elderly; PLMI = periodic limb movement index; QTVi = QT variability index; SBP = systolic BP; T90 = time of sleep spent below 90% oxygen saturation; TIA = transient ischemic attack.