Figure 3.

T-Coffee alignment of the transmembrane regions of Derlin-1, Derlin-2, and Derlin-3 from Homo sapiens and Der1 and Dfm1 from Saccharomyces cerevisiae. Identically and similarly conserved residues are highlighted in red and yellow, respectively. The hydrophilic cluster postulated to have a role in lipid distortion is underlined in green. The following are hydrophilic amino acids (in green) within the hydrophilic cluster implicated to participate in lipid thinning: Dfm1, RSSQ; Der1, NHSLT; Derlin-1, QYSTR; and Derlin-2,3, RYCRM.