TABLE 2.
Complete index of families of transport proteins in the TC systema
| TC no. (subclass) | Family |
|---|---|
| 1.A. α-Type channels | |
| 1.A.1 | Voltage-gated ion channel (VIC) superfamily |
| 1.A.2 | Animal inward rectifier K+ channel (IRK-C) family |
| 1.A.3 | Ryanodine-inositol 1,4,5-triphosphate receptor Ca2+ channel (RIR-CaC) family |
| 1.A.4 | Transient receptor potential Ca2+ channel (TRP-CC) family |
| 1.A.5 | Polycystine cation channel (PCC) family |
| 1.A.6 | Epithelial Na+ channel (ENaC) family |
| 1.A.7 | ATP-gated cation channel (ACC) family |
| 1.A.8 | Major intrinsic protein (MIP) family |
| 1.A.9 | Ligand-gated ion channel (LIC) family of neurotransmitter receptors |
| 1.A.10 | Glutamate-gated ion channel (GIC) family of neurotransmitter receptors |
| 1.A.11 | Chloride channel (CIC) family |
| 1.A.12 | Organellar chloride channel (O-CIC) family |
| 1.A.13 | Epithelial chloride channel (E-CIC) family |
| 1.A.14 | Nonselective cation channel-1 (NSCC1) family |
| 1.A.15 | Nonselective cation channel-2 (NSCC2) family |
| 1.A.16 | Yeast stretch-activated, cation-selective, Ca2+ channel, Mid1 (Mid1) family |
| 1.A.17 | Chloroplast outer envelope solute channel (CSC) family |
| 1.A.18 | Chloroplast envelope anion channel-forming Tic110 (Tic110) family |
| 1.A.19 | Influenza virus matrix-2 channel (IVC) family |
| 1.A.20 | gp91phox phagocyte NADPH oxidase-associated cytochrome b558 (CybB) H+ channel family |
| 1.A.21 | Bcl-2 (Bcl-2) family |
| 1.A.22 | Large conductance mechanosensitive ion channel (MscL) family |
| 1.A.23 | Small conductance mechanosensitive ion channel (MscS) family |
| 1.A.24 | Gap junction-forming connexin (connexin) family |
| 1.A.25 | Gap junction-forming innexin (innexin) family |
| 1.A.26 | Symbiotic ammonium transporter (SAT) family |
| 1.A.27 | Phospholemman (PLM) family |
| 1.A.28 | P21 holin S (P21 holin) family |
| 1.A.29 | λ holin S (λ holin) family |
| 1.A.30 | P2 holin TM (P2 holin) family |
| 1.A.31 | LydA holin (LydA holin) family |
| 1.A.32 | PRD1 holin M (PRD1 holin) family |
| 1.A.33 | T7 holin (T7 holin) family |
| 1.A.34 | HP1 holin (HP1 holin) family |
| 1.A.35 | T4 holin (T4 holin) family |
| 1.A.36 | T4 immunity holin (T4 immunity holin) family |
| 1.A.37 | φ29 holin (φ29 holin) family |
| 1.A.38 | φ11 holin (φ11 holin) family |
| 1.A.39 | φAdh holin (φAdh holin) family |
| 1.A.40 | φU53 holin (φU53 holin) family |
| 1.A.41 | LrgA holin (LrgA holin) family |
| 1.A.42 | ArpQ holin (ArpQ holin) family |
| 1.A.43 | Cph1 holin (Cph1 holin) family |
| 1.A.44 | Urea transporter (UT) family |
| 1.A.45 | H+- or Na+-translocating bacterial flagellar motor (Mot) family |
| 1.B. β-Barrel porins | |
| 1.B.1 | General bacterial porin (GBP) family |
| 1.B.2 | Chlamydial porin (CP) family |
| 1.B.3 | Sugar porin (SP) family |
| 1.B.4 | Brucella-Rhizobium porin (BRP) family |
| 1.B.5 | Pseudomonas OprP porin (POP) family |
| 1.B.6 | OmpA-OmpF porin (OOP) family |
| 1.B.7 | Rhodobacter PorCa porin (RPP) family |
| 1.B.8 | Mitochondrial and plastid porin (MPP) family |
| 1.B.9 | FadL outer membrane protein (FadL) family |
| 1.B.10 | Nucleoside-specific channel-forming outer membrane porin (Tsx) family |
| 1.B.11 | Outer membrane fimbrial usher porin (FUP) family |
| 1.B.12 | Autotransporter (AT) family |
| 1.B.13 | Alginate export porin (AEP) family |
| 1.B.14 | Outer membrane receptor (OMR) family |
| 1.B.15 | Raffinose porin (RafY) family |
| 1.B.16 | Short-chain amide and urea porin (SAP) family |
| 1.B.17 | Outer membrane factor (OMF) family |
| 1.B.18 | Outer membrane auxiliary (OMA) protein family |
| 1.B.19 | Glucose-selective OprB porin (OprB) family |
| 1.B.20 | Bacterial toxin export channel (TEC) family |
| 1.B.21 | OmpG porin (OmpG) family |
| 1.B.22 | Outer bacterial membrane secretin (secretin) family |
| 1.B.23 | Cyanobacterial porin (CBP) family |
| 1.B.24 | Mycobacterial porin (MBP) family |
| 1.B.25 | Outermembrane porin (Opr) family |
| 1.B.26 | Cyclodextrin porin (CDP) family |
| 1.C. Pore-forming toxins | |
| 1.C.1 | Channel-forming colicin (colicin) family |
| 1.C.2 | Channel-forming δ-endotoxin insecticidal crystal protein (ICP) family |
| 1.C.3 | α-Hemolysin channel-forming toxin (αHL) family |
| 1.C.4 | Aerolysin channel-forming toxin (aerolysin) family |
| 1.C.5 | Channel-forming ɛ-toxin (ɛ-toxin) family |
| 1.C.6 | Yeast killer toxin K1 (YKT-K1) family |
| 1.C.7 | Diphtheria toxin (DT) family |
| 1.C.8 | Botulinum and tetanus toxin (BTT) family |
| 1.C.9 | Vacuolating cytotoxin (VacA) family |
| 1.C.10 | Pore-forming hemolysin E (HlyE) family |
| 1.C.11 | Pore-forming RTX toxin (RTX-toxin) family |
| 1.C.12 | Thiol-activated cytolysin (TAC) family |
| 1.C.13 | Channel-forming leukocidin cytotoxin (Ctx) family |
| 1.C.14 | Cytohemolysin (CHL) family |
| 1.C.15 | Whipworm stichosome porin (WSP) family |
| 1.C.16 | Magainin (magainin) family |
| 1.C.17 | Cecropin (cecropin) family |
| 1.C.18 | Melittin (melittin) family |
| 1.C.19 | Defensin (defensin) family |
| 1.C.20 | Nisin (nisin) family |
| 1.C.21 | Lacticin 481 (lacticin 481) family |
| 1.C.22 | Lactococcin A (lactococcin A) family |
| 1.C.23 | Lactocin S (lactocin S) family |
| 1.C.24 | Pediocin (pediocin) family |
| 1.C.25 | Lactococcin G (lactococcin G) family |
| 1.C.26 | Lactacin X (lactacin X) family |
| 1.C.27 | Divergicin A (divergicin A) family |
| 1.C.28 | AS-48 (AS-48) family |
| 1.C.29 | Plantaricin EF (plantaricin EF) family |
| 1.C.30 | Plantaricin JK (plantaricin JK) family |
| 1.C.31 | Channel-forming colicin V (colicin V) family |
| 1.C.32 | Amphipathic peptide mastoparan (mastoparan) family |
| 1.C.33 | Cathilicidin (cathilicidin) family |
| 1.C.34 | Tachyplesin (tachyplesin) family |
| 1.C.35 | Amoebapore (amoebapore) family |
| 1.C.36 | Bacterial type III-target cell pore (IIITCP) family |
| 1.C.37 | Lactococcin 972 (lactococcin 972) family |
| 1.C.38 | Pore-forming equinatoxin (equinatoxin) family |
| 1.D. Non-ribosomally synthesized channels | |
| 1.D.1 | Gramicidin A (gramicidin A) channel family |
| 1.D.2 | Syringomycin channel-forming (syringomycin) family |
| 1.D.3 | Syringopeptin channel-forming (syringopeptin) family |
| 1.D.4 | Tolaasin channel-forming (tolassin) family |
| 1.D.5 | Alamethicin channel-forming (alamethicin) family |
| 1.D.6 | Complexed poly 3-hydroxybutyrate Ca2+ channel (cPHB-CC) family |
| 2.A. Porters: uniporters, symporters, and antiporters | |
| 2.A.1 | Major facilitator superfamily (MFS) |
| 2.A.1.1 | Sugar Porter (SP) family |
| 2.A.1.2 | Drug:H+ antiporter-1 (12 spanner) (DHA1) family |
| 2.A.1.3 | Drug:H+ antiporter-2 (14 spanner) (DHA2) family |
| 2.A.1.4 | Organophosphate:Pi antiporter (OPA) family |
| 2.A.1.5 | Oligosaccharide:H+ symporter (OHS) family |
| 2.A.1.6 | Metabolite:H+ symporter (MHS) family |
| 2.A.1.7 | Fucose:H+ symporter (FHS) family |
| 2.A.1.8 | Nitrate/nitrite porter (NNP) family |
| 2.A.1.9 | Phosphate:H+ symporter (PHS) family |
| 2.A.1.10 | Nucleoside:H+ symporter (NHS) family |
| 2.A.1.11 | Oxalate:formate antiporter (OFA) family |
| 2.A.1.12 | Sialate:H+ symporter (SHS) family |
| 2.A.1.13 | Monocarboxylate porter (MCP) family |
| 2.A.1.14 | Anion:cation symporter (ACS) family |
| 2.A.1.15 | Aromatic acid:H+ symporter (AAHS) family |
| 2.A.1.16 | Siderophore-iron transporter (SIT) family |
| 2.A.1.17 | Cyanate permease (CP) family |
| 2.A.1.18 | Polyol permease (PP) family |
| 2.A.1.19 | Organic cation transporter (OCT) family |
| 2.A.1.20 | Sugar efflux transporter (SET) family |
| 2.A.1.21 | Drug:H+ antiporter-3 (12 spanner) (DHA3) family |
| 2.A.1.22 | Vesicular neurotransmitter transporter (VNT) family |
| 2.A.1.23 | Conjugated bile salt transporter (BST) family |
| 2.A.1.24 | Unknown major facilitator-1 (UMF1) family |
| 2.A.1.25 | Peptide-acetyl-coenzyme A transporter (PAT) family |
| 2.A.1.26 | Unknown major facilitator-2 (UMF2) family |
| 2.A.1.27 | Phenyl propionate permease (PPP) family |
| 2.A.1.28 | Unknown major facilitator-3 (UMF3) family |
| 2.A.1.29 | Unknown major facilitator-4 (UMF4) family |
| 2.A.2 | Glycoside-pentoside-hexuronide (GPH):cation symporter family |
| 2.A.3 | Amino acid-polyamine-organocation (APC) superfamily |
| 2.A.3.1 | Amino acid transporter (AAT) family |
| 2.A.3.2 | Basic amino acid/polyamine antiporter (APA) family |
| 2.A.3.3 | Cationic amino acid transporter (CAT) family |
| 2.A.3.4 | Amino acid/choline transporter (ACT) family |
| 2.A.3.5 | Ethanolamine transporter (EAT) family |
| 2.A.3.6 | Archaeal/bacterial transporter (ABT) family |
| 2.A.3.7 | Glutamate:γ-aminobutyrate (GABA) antiporter (GGA) family |
| 2.A.3.8 | l-Type amino acid transporter (LAT) family |
| 2.A.3.9 | Spore germination protein (SGP) family |
| 2.A.3.10 | Yeast amino acid transporter (YAT) family |
| 2.A.4 | Cation diffusion facilitator (CDF) family |
| 2.A.5 | Zinc (Zn2+)-iron (Fe2+) permease (ZIP) family |
| 2.A.6 | Resistance-nodulation-cell division (RND) superfamily |
| 2.A.6.1 | Heavy metal efflux (HME) family |
| 2.A.6.2 | (Largely gram-negative bacterial) hydrophobe/amphiphile efflux-1 (HAE1) family |
| 2.A.6.3 | Putative nodulation factor exporter (NFE) family |
| 2.A.6.4 | SecDF (SecDF) family |
| 2.A.6.5 | (Gram-positive bacterial) hydrophobe/amphiphile efflux-2 (HAE2) family |
| 2.A.6.6 | Eukaryotic (putative) sterol transporter (EST) family |
| 2.A.6.7 | (Largely archaeal putative) hydrophobe/amphiphile efflux-3 (HAE3) family |
| 2.A.7 | Small multidrug resistance (SMR) family |
| 2.A.8 | Gluconate:H+ symporter (GntP) family |
| 2.A.9 | l-Rhamnose transporter (RhaT) family |
| 2.A.10 | 2-Keto-3-deoxygluconate transporter (KDGT) family |
| 2.A.11 | Citrate-Mg2+:H+ (CitM)–citrate:H+ (CitH) symporter (CitMHS) family |
| 2.A.12 | ATP:ADP antiporter (AAA) family |
| 2.A.13 | C4-dicarboxylate uptake (Dcu) family |
| 2.A.14 | Lactate permease (LctP) family |
| 2.A.15 | Betaine/Carnitine/Choline transporter (BCCT) family |
| 2.A.16 | Telurite resistance/dicarboxylate transporter (TDT) family |
| 2.A.17 | Proton-dependent oligopeptide transporter (POT) family |
| 2.A.18 | Amino acid/auxin permease (AAAP) family |
| 2.A.19 | Ca2+:cation antiporter (CaCA) family |
| 2.A.20 | Inorganic phosphate transporter (PiT) family |
| 2.A.21 | Solute:sodium symporter (SSS) family |
| 2.A.22 | Neurotransmitter:sodium symporter (NSS) family |
| 2.A.23 | Dicarboxylate/amino acid:cation (Na+ or H+) symporter (DAACS) family |
| 2.A.24 | Citrate:cation symporter (CCS) family |
| 2.A.25 | Alanine or glycine:cation symporter (AGCS) family |
| 2.A.26 | Branched-chain amino acid:cation symporter (LIVCS) family |
| 2.A.27 | Glutamate:Na+ symporter (ESS) family |
| 2.A.28 | Bile acid:Na+ symporter (BASS) family |
| 2.A.29 | Mitochondrial carrier (MC) family |
| 2.A.30 | Cation-chloride cotransporter (CCC) family |
| 2.A.31 | Anion Exchanger (AE) family |
| 2.A.32 | Silicon transporter (Sit) family |
| 2.A.33 | NhaA Na+:H+ antiporter (NhaA) family |
| 2.A.34 | NhaB Na+:H+ antiporter (NhaB) family |
| 2.A.35 | NhaC Na+:H+ antiporter (NhaC) family |
| 2.A.36 | Monovalent cation:proton antiporter-1 (CPA1) family |
| 2.A.37 | Monovalent cation:proton antiporter-2 (CPA2) family |
| 2.A.38 | K+ transporter (Trk) family |
| 2.A.39 | Nucleobase:cation symporter-1 (NCS1) family |
| 2.A.40 | Nucleobase:cation symporter-2 (NCS2) family |
| 2.A.41 | Concentrative nucleoside transporter (CNT) family |
| 2.A.42 | Hydroxyl/aromatic amino acid permease (HAAAP) family |
| 2.A.43 | Lysosomal cystine transporter (LCT) family |
| 2.A.44 | Formate-nitrite transporter (FNT) family |
| 2.A.45 | Arsenite-antimonite (ArsB) efflux family |
| 2.A.46 | Benzoate:H+ symporter (BenE) family |
| 2.A.47 | Divalent anion:Na+ symporter (DASS) family |
| 2.A.48 | Reduced folate carrier (RFC) family |
| 2.A.49 | Ammonium transporter (Amt) family |
| 2.A.50 | Triose-phosphate/nucleoside-sugar transporter (TP-NST) family |
| 2.A.51 | Chromate ion transporter (CHR) family |
| 2.A.52 | Ni2+-Co2+ transporter (NiCoT) family |
| 2.A.53 | Sulfate permease (SulP) family |
| 2.A.54 | Mitochondrial tricarboxylate carrier (MTC) family |
| 2.A.55 | Metal ion (Mn2+-ion) transporter (Nramp) family |
| 2.A.56 | Tripartite ATP-independent periplasmic transporter (TRAP-T) family |
| 2.A.57 | Equilibrative nucleoside transporter (ENT) family |
| 2.A.58 | Phosphate:Na+ symporter (PNaS) family |
| 2.A.59 | Arsenical resistance-3 (ACR3) family |
| 2.A.60 | Organo anion transporter (OAT) family |
| 2.A.61 | C4-dicarboxylate uptake C (DcuC) family |
| 2.A.62 | NhaD Na+:H+ antiporter (NhaD) family |
| 2.A.63 | Monovalent cation (K+ or Na+):proton antiporter-3 (CPA3) family |
| 2.A.64 | Type V secretory pathway or twin-arginine-targeting (Tat) family |
| 2.A.65 | Bilirubin transporter (BRT) family |
| 2.A.66 | Multi antimicrobial extrusion (MATE) family |
| 2.A.67 | Oligopeptide transporter (OPT) family |
| 2.A.68 | p-Aminobenzoyl-glutamate transporter (AbgT) family |
| 2.A.69 | Auxin efflux carrier (AEC) family |
| 2.A.70 | Malonate:Na+ symporter (MSS) family |
| 2.A.71 | Folate-biopterin transporter (FBT) family |
| 2.A.72 | K+ uptake permease (KUP) family |
| 2.A.73 | Inorganic carbon (HCO3−) transporter (ICT) family |
| 2.A.74 | 4-TMS multidrug endosomal transporter (MET) family |
| 2.A.75 | l-Lysine exporter (LysE) family |
| 2.A.76 | Resistance to homoserine/threonine (RhtB) family |
| 2.A.77 | Cadmium resistance (CadD) family |
| 2.A.78 | Carboxylate/amino acid/amine transporter (CAAT) family |
| 2.B Non-ribosomally synthesized porters | |
| 2.B.1 | Valinomycin carrier (valinomycin) family |
| 2.B.2 | Monensin (monensin) family |
| 2.B.3 | Nigericin (nigericin) family |
| 2.B.4 | Macrotetrolide antibiotic (MA) family |
| 2.B.5 | Macrocyclic polyether (MP) family |
| 2.C Ion gradient-driven energizers | |
| 2.C.1 | TonB-ExbB-ExbD/TolA-TolQ-TolR (TonB) family of auxiliary proteins for energization of outer membrane receptor (OMR)-mediated active transport |
| 3.A Diphosphate bond hydrolysis-driven transporters | |
| 3.A.1 | ATP-binding cassette (ABC) superfamily |
| ABC-type uptake permeases (All from prokaryotes [bacteria and archaea]) | |
| 3.A.1.1 | Carbohydrate uptake transporter-1 (CUT1) family |
| 3.A.1.2 | Carbohydrate uptake transporter-2 (CUT2) family |
| 3.A.1.3 | Polar amino acid uptake transporter (PAAT) family |
| 3.A.1.4 | Hydrophobic amino acid uptake transporter (HAAT) family |
| 3.A.1.5 | Peptide/opine/nickel uptake transporter (PepT) family |
| 3.A.1.6 | Sulfate uptake transporter (SulT) family |
| 3.A.1.7 | Phosphate uptake transporter (PhoT) family |
| 3.A.1.8 | Molybdate uptake transporter (MolT) family |
| 3.A.1.9 | Phosphonate uptake transporter (PhnT) family |
| 3.A.1.10 | Ferric iron uptake transporter (FeT) family |
| 3.A.1.11 | Polyamine/opine/phosphonate uptake transporter (POPT) family |
| 3.A.1.12 | Quaternary amine uptake transporter (QAT) family |
| 3.A.1.13 | Vitamin B12 uptake transporter (VB12T) family |
| 3.A.1.14 | Iron chelate uptake transporter (FeCT) family |
| 3.A.1.15 | Manganese/zinc/iron chelate uptake transporter (MZT) family |
| 3.A.1.16 | Nitrate/nitrite/cyanate uptake transporter (NitT) family |
| 3.A.1.17 | Taurine uptake transporter (TauT) family |
| 3.A.1.18 | Putative cobalt uptake transporter (CoT) family |
| 3.A.1.19 | Thiamine uptake transporter (ThiT) family |
| 3.A.1.20 | Brachyspira iron transporter (BIT) family |
| ABC-type efflux permeases (prokaryotic) | |
| 3.A.1.101 | Capsular polysaccharide exporter (CPSE) family |
| 3.A.1.102 | Lipooligosaccharide exporter (LOSE) family |
| 3.A.1.103 | Lipopolysaccharide exporter (LPSE) family |
| 3.A.1.104 | Teichoic acid exporter (TAE) family |
| 3.A.1.105 | Drug exporter (DrugE1) family |
| 3.A.1.106 | Putative lipid A exporter (LipidE) family |
| 3.A.1.107 | Putative heme exporter (HemeE) family |
| 3.A.1.108 | β-Glucan exporter (GlucanE) family |
| 3.A.1.109 | Protein-1 exporter (Prot1E) family |
| 3.A.1.110 | Protein-2 exporter (Prot2E) family |
| 3.A.1.111 | Peptide-1 exporter (Pep1E) family |
| 3.A.1.112 | Peptide-2 exporter (Pep2E) family |
| 3.A.1.113 | Peptide-3 exporter (Pep3E) family |
| 3.A.1.114 | Probable glycolipid exporter (DevE) family |
| 3.A.1.115 | Na+ exporter (NatE) family |
| 3.A.1.116 | Microcin B17 exporter (McbE) family |
| 3.A.1.117 | Drug exporter-2 (DrugE2) family |
| 3.A.1.118 | Microcin J25 exporter (McjD) family |
| 3.A.1.119 | Drug/siderophore exporter-3 (DrugE3) family |
| ABC-type efflux permeases (mostly eukaryotic) | |
| 3.A.1.201 | Multidrug resistance exporter (MDR) family |
| 3.A.1.202 | Cystic fibrosis transmembrane conductance exporter (CFTR) family |
| 3.A.1.203 | Peroxysomal fatty acyl coenzyme A transporter (FAT) family |
| 3.A.1.204 | Eye pigment precursor transporter (EPP) family |
| 3.A.1.205 | Pleiotropic drug resistance (PDR) family |
| 3.A.1.206 | a-Factor sex pheromone exporter (STE) family |
| 3.A.1.207 | Conjugate transporter-1 (CT1) family |
| 3.A.1.208 | Conjugate transporter-2 (CT2) family |
| 3.A.1.209 | Major histocompatibility complex peptide transporter (TAP) family |
| 3.A.1.210 | Heavy-metal transporter (HMT) family |
| 3.A.2 | H+- or Na+-translocating F-type, V-type, and A-type ATPase (F-ATPase) superfamily |
| 3.A.3 | P-type ATPase (P-ATPase) superfamily |
| 3.A.4 | Arsenite-antimonite (ArsAB) efflux family |
| 3.A.5 | Type II (general) secretory pathway (IISP) family |
| 3.A.6 | Type III (virulence-related) secretory pathway (IIISP) family |
| 3.A.7 | Type IV (conjugal DNA-protein transfer or VirB) secretory pathway (IVSP) family |
| 3.A.8 | Mitochondrial protein translocase (MPT) family |
| 3.A.9 | Chloroplast envelope protein translocase (CEPT or Tic-Toc) family |
| 3.A.10 | H+-translocating pyrophosphatase (H+-PPase) family |
| 3.A.11 | Bacterial competence-related DNA transformation transporter (DNA-T) family |
| 3.B. Decarboxylation-driven active transporters | |
| 3.B.1 | Na+-transporting carboxylic acid decarboxylase (NaT-DC) family |
| 3.C. Methyl transfer-driven transporters | |
| 3.C.1 | Na+-transporting methyltetrahydromethanopterin:coenzyme M methyltransferase (NaT-MMM) family |
| 3.D. Oxidoreduction-driven active transporters | |
| 3.D.1 | Proton/sodium-translocating NADH dehydrogenase (NDH) family |
| 3.D.2 | Proton-translocating transhydrogenase (PTH) family |
| 3.D.3 | Proton-translocating quinol:cytochrome c reductase (QCR) superfamily |
| 3.D.4 | Proton-translocating cytochrome oxidase (COX) superfamily |
| 3.D.5 | Na+-translocating NADH:quinone dehydrogenase (Na-NDH) family |
| 3.D.6 | Putative ion (H+ or Na+)-translocating NADH:ferredoxin oxidoreductase (NFO) family |
| 3.D.7 | H2:heterodisulfide/oxidoreductase (HHO) family |
| 3.D.8 | Na+- or H+-pumping formyl methanofuran dehydrogenase (FMF-DH) family |
| 3.E. Light-driven active transporters | |
| 3.E.1 | Ion-translocating fungal/archaeal rhodopsin (FAR) family |
| 3.E.2 | Photosynthetic reaction center (PRC) family |
| 4.A. Phosphoryl transfer-driven group translocators | |
| 4.A.1 | PTS glucose-glucoside (Glc) family |
| 4.A.2 | PTS fructose-mannitol (Fru) family |
| 4.A.3 | PTS lactose-N,N′-diacetylchitobiose-β-glucoside (Lac) family |
| 4.A.4 | PTS glucitol (Gut) family |
| 4.A.5 | PTS galactitol (Gat) family |
| 4.A.6 | PTS Mannose-fructose-sorbose (Man) family |
| 8.A. Auxiliary transport proteins | |
| 8.A.1 | Membrane fusion protein (MFP) family |
| 8.A.2 | Secretin auxiliary lipoprotein (SAL) family |
| 8.A.3 | Cytoplasmic membrane-periplasmic auxiliary-1 (MPA1) protein with cytoplasmic (C) domain (MPA1−C or MPA1+C) family |
| 8.A.4 | Cytoplasmic membrane-periplasmic auxiliary-2 (MPA2) family |
| 8.A.5 | Voltage-gated K+ channel β-subunit (VICβ) family |
| 8.A.7 | Phosphotransferase system enzyme I (EI) family |
| 8.A.8 | Phosphotransferase system HPr (HPr) family |
| 8.A.9 | rBAT transport accessory protein (rBAT) family |
| 8.A.10 | Slow voltage-gated K+ channel accessory protein (MinK) family |
| 8.A.11 | Phospholamban (Ca2+-ATPase regulator) (PLB) family |
| 8.A.12 | ABC bacteriocin exporter accessory protein (BEA) family |
| 8.A.13 | Tetratricopeptide repeat (Tpr1) family |
| 9.A. Transporters of Unknown Classification | |
| 9.A.1 | Polysaccharide transporter (PST) family |
| 9.A.2 | MerTP mercuric ion (Hg2+) permease (MerTP) family |
| 9.A.3 | MerC mercuric ion (Hg2+) uptake (MerC) family |
| 9.A.4 | Nicotinamide mononucleotide (NMN) uptake permease (PnuC) family |
| 9.A.5 | Cytochrome oxidase biogenesis (Oxa1) family |
| 9.A.6 | Intracellular nucleoside transporter (INT) family |
| 9.A.8 | Ferrous iron uptake (FeoB) family |
| 9.A.9 | Low-affinity Fe2+ transporter (FeT) family |
| 9.A.10 | Oxidase-dependent Fe2+ transporter (OFeT) family |
| 9.A.11 | Copper transporter-1 (Ctr1) family |
| 9.A.12 | Copper transporter-2 (Ctr2) family |
| 9.A.13 | Short-chain fatty acid transporter (scFAT) family |
| 9.A.14 | Nuclear pore complex (NPC) family |
| 9.A.15 | Putative amide transporter (Ami) family |
| 9.A.16 | Septal DNA translocator (SDT) family |
| 9.A.17 | Metal ion transporter (MIT) family |
| 9.A.18 | Peptide uptake permease (PUP) family |
| 9.A.19 | Mg2+ transporter-E (MgtE) family |
| 9.A.20 | Low-affinity cation transporter (LCT) family |
| 9.B. Putative uncharacterized transporters | |
| 9.B.1 | Metal homeostasis protein (MHP) family |
| 9.B.2 | Ca2+ homeostasis protein (CHP) family |
| 9.B.3 | Putative bacterial murein precursor exporter (MPE) family |
| 9.B.4 | Putative efflux transporter (PET) family |
| 9.B.5 | KX blood group antigen (KXA) family |
| 9.B.6 | Toxic Hok/Gef protein (Hok/Gef) family |
| 9.B.7 | Putative bacteriochlorophyll delivery (BCD) family |
| 9.B.8 | Canalicular bile acid transporter (C-BAT) family |
| 9.B.9 | Urate transporter (UAT) family |
| 9.B.10 | 6TMS putative MarC transporter (MarC) family |
| 9.B.11 | Mitochondrial mRNA splicing-2 protein (MRS2) family |
| 9.B.12 | Stress (salt or low-temperature)-induced hydrophobic peptide (SHP) family |
| 9.B.13 | Putative pore-forming entericidin (ECN) family |
| 9.B.14 | Putative heme exporter protein (HEP) family |
| 9.B.15 | Putative chloroquine resistance Na+/H+ exchanger of Plasmodium falciparum (CQR) family |
| 9.B.16 | Putative ductin channel (ductin) family |
| 9.B.17 | Putative fatty acid transporter (FAT) family |
| 9.B.18 | SecDF-associated single transmembrane protein (SSTP) family |
| 9.B.19 | Mn2+ homeostasis protein (MnHP) family |
| 9.B.20 | Putative Mg2+ transporter-C (MgtC) family |
| 9.B.21 | Frataxin (frataxin) family |
| 9.B.22 | Putative permease (PerM) family |
| 9.B.23 | Verapamil-reversible chloroquine resistance (VCR) family |
| 9.B.24 | Testis-enhanced gene transfer (TEGT) family |
| 9.B.25 | YbbM (YbbM) family |
| 9.B.26 | PF27 (PF27) family |
| 9.B.27 | YdjX-Z (YdjX-Z) family |
| 9.B.28 | YqaE (YqaE) family |
| 9.B.29 | YebN (YebN) family |
| 9.B.30 | Hly III (Hly III) family |
| 9.B.31 | YqiH (YqiH) family |
| 9.C. Functionally characterized transporters with unidentified sequences | |
| 9.C.1 | Endosomal oligosaccharide transporters (EOT) |
| 9.C.2 | Volume-sensitive anion channels (VAC) |
| 9.C.3 | Rhodococcus erythropolis porin (REP) family |
a
The approved abbreviation for each family listed is given in parentheses.