TABLE 22.
Transporter families including nontransporter homologs
| Family | TC no. | Occurrence | Nontransporter homolog | TC no. | Organism |
|---|---|---|---|---|---|
| MFS | 2.A.1 | BAE | Low-glucose Tx sensor, Snf3p | 2.A.1.1.18 | S. cerevisiae |
| High-glucose Tx sensor, Rgt2p | 2.A.1.1.19 | S. cerevisiae | |||
| Glucose 6-phosphate Tx sensor, UhpC | 2.A.1.4.4 | E. coli | |||
| APC | 2.A.3 | BAE | Leucine Tx sensor, Ssy1p | 2.A.3.1.20 | S. cerevisiae |
| RND | 2.A.6 | BAE | “Patched” polarity Tx receptor | 2.A.6.6.2 | D. melanogaster |
| SREBP cleavage-activating protein, SCAP | 2.A.6.6.4 | C. griseus | |||
| HMG-CoA reductase | 2.A.6.6.5 | H. sapiens | |||
| AMT | 2.A.49 | BAE | NH4+ transporter and sensor, Mep2p | 2.A.49.3.2 | S. cerevisiae |
| BR | 3.E.1 | AE | Sensory rhodopsin | 3.E.1.3.1 | H. salinarum |
| Heat and shock protein, HSP30 | 3.E.1.4.1 | S. cerevisiae | |||
| ABC | 3.A.1 | BAE | SUR1 sulfonylurea receptor; regulator of ATP-sensitive K+ channels | 3.A.1.68.4 | H. sapiens |
| Cytoplasmic and periplasmic protein homologs function in other capacities (Tx, receptors, energizers) | — | Bacteria; animals | |||
| PTS | 4.A.1–4.A.6 | B | sacX transcriptional regulator | 4.A.1.2.1 | Bacillus subtilis |
| Permeases are generally sugar kinases, but cytoplasmic proteins may function in regulation | — | Bacteria |