TABLE 9.
Classification of outer membrane porins (most from gram-negative bacteria) according to substrate specificity
| Substrate | TC no. | Family(-ies) |
|---|---|---|
| I.A. Nonselective | ||
| Nonselective | 1.B.1, -2, -4, -6, -7, -8, -21, -23–26 | GBP, CP, BRP, OOP, RPP, MPP, OmpG, CBP, MBP, Opr, CDP |
| Nonselective (slight cation selectivity) | 1.B.15.1.1 | RafY |
| I.C. Cations | ||
| Fe3+ or Fe3+ chelate selective | 1.B.14.3.2 | OMR |
| Metal ions | 1.B.17.2.1 | OMF |
| Metal ions | 1.B.17.2.2 | OMF |
| I.D. Anions | ||
| Anion selective | 1.B.1.6.1 | GBP |
| Anion selective | 1.B.8 | MPP |
| Anion selective | 1.B.13 | AEP |
| Phosphate selective | 1.B.1.1.2 | GBP |
| Phosphate selective | 1.B.5.1.1 | POP |
| Pyrophosphate selective | 1.B.5.1.2 | POP |
| II.A. Sugars and polyols | ||
| Glucose | 1.B.19.1.1 | OprB |
| Maltooligosaccharide selective | 1.B.3.1.1 | SP |
| Oligosaccharide selective | 1.B.3.1.2 | SP |
| II.B. Monocarboxylates | ||
| Fatty acid selective | 1.B.9.1.1 | FadL |
| II.E. Others | ||
| Toluene selective | 1.B.9.2.1 | FadL |
| III.A. Amides | ||
| Amides, short chain | 1.B.16.1.1 | SAP |
| Urea | 1.B.16.1.1 | SAP |
| IV.B. Nucleosides | ||
| Nucleoside selective | 1.B.10.1.1 | Tsx |
| IV.C. Nucleotides | ||
| Nucleotide selective | 1.B.1.1.4 | GBP |
| V.A. Vitamins | ||
| Cobalamin selective | 1.B.14.3.1 | OMR |
| V.B. Enzyme and redox cofactors | ||
| Heme | 1.B.14.2.3 | OMR |
| Porphyrin | 1.B.14.3.1 | OMR |
| V.C. Iron-siderophores | ||
| Iron complex selective | 1.B.14.1.1–4; 1.B.14.2–3 | OMR |
| Fe3+-catecholate | 1.B.14.3.2 | OMR |
| Fe3+-citrate | 1.B.14.1.2 | OMR |
| Fe3+-coprogen | 1.B.14.1.3 | OMR |
| Fe3+-enterobactin | 1.B.14.1.1 | OMR |
| Ferrichrome | 1.B.14.1.4 | OMR |
| Heme | 1.B.14.2.3 | OMR |
| Heme | 1.B.20.3.1 | TEC |
| VI.A. Multiple drugs | ||
| Drug (multiple) selective | 1.B.17.1.1 | OMF |
| Drug (multiple) selective | 1.B.17.3.2 | OMF |
| Drug (multiple) selective | 1.B.17.3.3 | OMF |
| VII.A. Carbohydrates | ||
| Alginate (acidic polysaccharide) | 1.B.13.1.1 | AEP |
| Capsular or exopolysaccharide selective | 1.B.18.1.1–2; 1.B.18.2.1 | OMA |
| Lipooligosaccharide selective | 1.B.17.3.1 | OMF |
| Polymannonate | 1.B.13.1.1 | AEP |
| Polysaccharide selective | 1.B.13.1.1 | AEP |
| VII.B. Proteins | ||
| Albomycin | 1.B.14.1.4 | OMR |
| Colicin I selective | 1.B.14.3.2 | OMR |
| Colicin M selective | 1.B.14.1.4 | OMR |
| Colicin B selective | 1.B.14.1.1 | OMR |
| Colicin D selective | 1.B.14.1.1 | OMR |
| Fimbrial subunit selective | 1.B.11.1–3 | FUP |
| Hemin selective | 1.B.14.2.3 | OMR |
| Hemoglobin selective | 1.B.14.2.2 | OMR |
| Protein (virulence factor) selective | 1.B.12 | AT |
| Protein (hemolysin) selective | 1.B.17.1.1 | OMF |
| Protein (hemolysin) selective | 1.B.20.1.2 | TEC |
| Protein (hemagglutinin) selective | 1.B.20.2.1 | TEC |
| Protein (proteases) selective | 1.B.17.1.2 | OMF |
| Protein (cyclolysin) selective | 1.B.17.2.3 | OMF |
| Protein (toxin) selective | 1.B.20.1.1 | TEC |
| Transferrin selective | 1.B.14.2.1 | OMR |
| Protein (competence factor) selective | 1.B.22.1.6 | Secretin |
| Protein (secretory protein) selective | 1.B.22.1.1 | Secretin |
| Protein (fimbrial subunit) selective | 1.B.22.1.3 | Secretin |
| Protein (virulence factor) selective | 1.B.22.1.2; 1.B.22.1.4; 1.B.22.1.5 | Secretin |
| Protein (phage) selective | 1.B.22.1.7 | Secretin |