Table 6. Logistic regression analysis for the odds ratio (95% C.I.) of atherogenic dyslipidemia.
| Wakeup frequency | Insomnia | Wakeup frequency ＊Insomnia | Relative excess risk due to interaction (RERI) | Attributable proportion (AP) | ||
|---|---|---|---|---|---|---|
| No | Yes | |||||
| All participants | ||||||
| sdLDL-C ≥ 75th percent | ＜ 2 | 1 | 1.04 (0.49, 2.18) | 1.03 (0.40.2.67) | 0.06 (-1.16, 1.28) | 0.04 (-0.72, 0.79) |
| ≥ 2 | 1.50 (1.03, 2.19) | 1.59 (0.91, 2.80) | ||||
| TCHO/HDL-C ≥ 5 | ＜ 2 | 1 | 0.44 (0.20, 1.01) | 2.45 (0.88, 6.77) | 0.69 (-0.38, 1.76) | 0.41 (-0.07, 0.90) |
| ≥ 2 | 1.53 (1.05, 2.21) | 1.66 (0.94, 2.92) | ||||
| Non-HDL-C ≥ 160 mg/dL | ＜ 2 | 1 | 1.07 (0.57, 2.00) | 2.15 (0.89.5.21) | 1.50 (-0.21, 3.21) | 0.54 (0.17, 0.91) |
| ≥ 2 | 1.21 (0.86, 1.70) | 2.78 (1.55, 4.98) | ||||
| TG ≥ 200 mg/dL | ＜ 2 | 1 | 1.45 (0.72, 2.92) | 0.91 (0.36, 2.32) | -0.02 (-1.45, 1.40) | -0.01 (-0.83, 0.80) |
| ≥ 2 | 1.33 (0.90, 1.96) | 1.76 (0.99, 3.12) | ||||
| TCHO ≥ 200 mg/dL | ＜ 2 | 1 | 1.20 (0.63, 2.30) | 2.18 (0.85, 5.55) | 1.39 (-0.39, 3.17) | 0.54 (0.11, 0.97) |
| ≥ 2 | 0.98 (0.70, 1.39) | 2.58 (1.36, 4.90) | ||||
| Dyslipidemia | ＜ 2 | 1 | 1.15 (0.58, 2.27) | 1.69 (0.66, 4.28) | 1.00 (-0.58, 2.58) | 0.42 (-0.07, 0.91) |
| ≥ 2 | 1.22 (0.85, 1.77) | 2.37 (1.31, 4.30) | ||||
| Male | ||||||
| sdLDL-C ≥ 75th percent | ＜ 2 | 1 | 1.25 (0.52, 3.02) | 1.06 (0.31, 3.56) | 0.17 (-1.57, 1.90) | 0.10 (-0.87, 1.07) |
| ≥ 2 | 1.29 (0.81, 2.07) | 1.71 (0.78, 3.72) | ||||
| TCHO/HDL-C ≥ 5 | ＜ 2 | 1 | 0.53 (0.21, 1.31) | 3.43 (1.01, 11.66) | 1.40 (-0.25, 3.04) | 0.68 (0.27, 1.08) |
| ≥ 2 | 1.14 (0.73, 1.78) | 2.06 (0.96, 4.43) | ||||
| Non-HDL-C ≥ 160 mg/dL | ＜ 2 | 1 | 0.87 (0.40, 1.89) | 3.33 (1.05, 10.54) | 2.05 (-0.37, 4.46) | 0.70 (0.35, 1.05) |
| ≥ 2 | 1.01 (0.67, 1.52) | 2.93 (1.31, 6.55) | ||||
| TG ≥ 200 mg/dL | ＜ 2 | 1 | 1.80 (0.77, 4.17) | 0.68 (0.20, 2.27) | -0.53 (-2.46, 1.40) | -0.36 (-1.85, 1.12) |
| ≥ 2 | 1.20 (0.75, 1.93) | 1.47 (0.66, 3.27) | ||||
| TCHO ≥ 200 mg/dL | ＜ 2 | 1 | 1.04 (0.48, 2.25) | 2.43 (0.77, 7.65) | 1.28 (-0.61, 3.17) | 0.59 (0.08, 1.09) |
| ≥ 2 | 0.87 (0.58, 1.30) | 2.19 (0.98, 4.87) | ||||
| Dyslipidemia | ＜ 2 | 1 | 1.16 (0.50, 2.68) | 1.92 (0.56, 6.61) | 1.28 (-1.11, 3.68) | 0.49 (-0.09, 1.07) |
| ≥ 2 | 1.18 (0.76, 1.83) | 2.62 (1.12, 6.11) | ||||
| Female | ||||||
| sdLDL-C ≥ 75th percent | ＜ 2 | 1 | 0.77 (0.19, 3.12) | 0.99 (0.19, 5.26) | -0.26 (-2.24, 1.72) | -0.17 (-1.50, 1.16) |
| ≥ 2 | 2.06 (1.05, 4.02) | 1.56 (0.67, 3.65) | ||||
| TCHO/HDL-C ≥ 5 | ＜ 2 | 1 | 0.22 (0.02, 2.00) | 1.82 (0.17, 19.93) | -1.22 (-3.71, 1.27) | -0.89 (-3.06, 1.28) |
| ≥ 2 | 3.36 (1.64, 6.91) | 1.37 (0.54, 3.48) | ||||
| Non-HDL-C ≥ 160 mg/dL | ＜ 2 | 1 | 1.54 (0.49, 4.87) | 0.96 (0.21, 4.33) | 0.44 (-2.76, 3.65) | 0.14 (-0.82, 1.11) |
| ≥ 2 | 2.06 (1.06, 4.01) | 3.05 (1.27, 7.34) | ||||
| TG ≥ 200 mg/dL | ＜ 2 | 1 | 1.10 (0.26, 4.56) | 1.18 (0.21, 6.53) | 0.39 (-2.01, 2.80) | 0.18 (-0.87, 1.23) |
| ≥ 2 | 1.65 (0.80, 3.40) | 2.14 (0.90, 5.09) | ||||
| TCHO ≥ 200 mg/dL | ＜ 2 | 1 | 1.58 (0.44, 5.68) | 1.69 (0.28, 10.07) | 1.93 (-2.91, 6.77) | 0.48 (-0.30, 1.26) |
| ≥ 2 | 1.50 (0.74, 3.06) | 4.01 (1.29, 12.45) | ||||
| Dyslipidemia | ＜ 2 | 1 | 1.28 (0.38, 4.31) | 1.25 (0.27, 5.80) | 0.53 (-1.83, 2.90) | 0.24 (-0.73, 1.22) |
| ≥ 2 | 1.37 (0.70, 2.68) | 2.18 (0.93, 5.13) | ||||
Adjusted variables: Age, sex, fasting glucose, body mass index, systolic blood pressure, habits of smoking, alcohol consumption, exercise, and use of sleeping pills.
Definition: Insomnia was defined as self-reported moderate (2-3 times per week) to severe (≥ 4 days per week) insomnia.
Relative excess risk due to interaction (RERI) = OR (Insomnia: Yes, Wakeup frequency ≥ 2) –OR (Insomnia: Yes, Wakeup frequency ＜2) - OR (Insomnia: No, Wakeup frequency ≥ 2) + 1; Attributable proportion (AP) = RERI / OR (Insomnia: Yes, Wakeup frequency ≥ 2)