Supplemental Table 1. Associations of ALDH2 rs671 polymorphism with levels of HDL-C and CEC .
| HDL-C (mg/dl) | CEC | |||||||
|---|---|---|---|---|---|---|---|---|
| Bi-variable model | Multivariable model 1 | Bi-variable model | Multivariable model 1 | |||||
| B (SE) | P value | B (SE)† | P value | B (SE) | P value | B (SE) † | P value | |
| All subjects | ||||||||
| ALDH2 ＊1/＊1 genotype | 0 | 0 | 0 | 0 | ||||
| ALDH2 ＊1/＊2 or ＊2/＊2 genotype | -5.15 (1.36) | ＜0.001 | -4.19 (1.24) | 0.001 | -2.60 (1.27) | 0.040 | -2.02 (1.26) | 0.109 |
| Subjects with no drinking habit | ||||||||
| ALDH2 ＊1/＊1 genotype | 0 | 0 | 0 | 0 | ||||
| ALDH2 ＊1/＊2 or ＊2/＊2 genotype | -5.96 (2.47) | 0.017 | -4.82 (2.24) | 0.033 | -6.00 (2.26) | 0.009 | -4.75 (2.24) | 0.035 |
| Subjects with drinking habit | ||||||||
| ALDH2 ＊1/＊1 genotype | 0 | 0 | 0 | 0 | ||||
| ALDH2 ＊1/＊2 or ＊2/＊2 genotype | -2.99 (1.78) | 0.094 | -2.15 (1.64) | 0.192 | -0.60 (1.67) | 0.733 | -0.30 (1.68) | 0.858 |
†Adjusted by age, BMI ≥ 25 kg/m2, LDL-C, Log-TGs and smoking status.
ALDH2, aldehyde dehydrogenase 2; HDL-C, high-density lipoprotein cholesterol; CEC, cholesterol efflux capacity; B, unstandardized regression coefficients; SE, standard error; BMI, body mass index; LDL-C, low-density lipoprotein cholesterol; TGs, triglycerides.