Table 3. Associations of levels of HDL-C and CEC with drinking habit categories using multiple regression analysis.
| HDL-C (mg/dl) | CEC | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Bi-variable model | Multivariable model 1 | Bi-variable model | Multivariable model 1 | Multivariable model 2 | ||||||
| B (SE) | P value | B (SE)† | P value | B (SE) | P value | B (SE)† | P value | B (SE)‡ | P value | |
| Drinking habit categories | ||||||||||
| No drinking habit | 0 | 0 | ＜0.001§ | 0 | 0 | 0 | 0.060§ | |||
| ＜23 g/day | 4.47 (1.61) | 0.006 | 2.28 (1.50) | 0.129 | 2.80 (1.50) | 0.063 | 1.03 (1.55) | 0.506 | -0.19 (1.33) | 0.889 |
| 23-45.9 g/day | 5.57 (1.99) | 0.005 | 4.85 (1.90) | 0.011 | 1.52 (1.86) | 0.414 | 1.42 (1.96) | 0.468 | -1.16 (1.69) | 0.493 |
| ≥ 46 g/day | 8.61 (2.49) | 0.001 | 9.51 (2.34) | ＜0.001 | 0.04 (2.32) | 0.987 | 0.63 (2.41) | 0.795 | -4.43 (2.10) | 0.035|| |
| Combination of the ALDH2 genotype and drinking habit categories | ||||||||||
| ＊1/＊1 & no drinking habit | 0 | 0 | §§ | 0 | 0 | 0 | §§§ | |||
| ＊1/＊1 & ＜23 g/day | 1.69 (2.61) | 0.519 | 1.12 (2.33) | 0.632 | -1.93 (2.44) | 0.428 | -2.41 (2.39) | 0.315 | -3.01 (2.04) | 0.142 |
| ＊1/＊1 & 23-45.9 g/day | 0.94 (2.87) | 0.745 | 2.56 (2.59) | 0.324 | -1.38 (2.68) | 0.606 | 0.01 (2.66) | 0.997 | -1.36 (2.27) | 0.549 |
| ＊1/＊1 & ≥ 46 g/day | 5.70 (3.34) | 0.089 | 8.44 (3.01) | 0.005 | -3.47 (3.12) | 0.266 | -1.78 (3.09) | 0.565 | -6.30 (2.66) | 0.018|| |
| ＊2 allele & no drinking habit | -5.96 (2.65) | 0.025|| | -4.07 (2.38) | 0.089 | -6.00 (2.47) | 0.015|| | -4.79 (2.45) | 0.051 | -2.61 (2.10) | 0.213 |
| ＊2 allele & ＜23 g/day | -2.00 (2.80) | 0.474 | -1.39 (2.52) | 0.582 | -0.76 (2.60) | 0.769 | -0.92 (2.59) | 0.722 | -0.18 (2.21) | 0.937 |
| ＊2 allele & 23-45.9 g/day | 2.61 (3.93) | 0.507 | 4.59 (3.54) | 0.196 | -7.10 (3.66) | 0.053 | -5.11 (3.64) | 0.161 | -7.57 (3.11) | 0.015|| |
| ＊2 allele & ≥ 46 g/day | 0.28 (4.91) | 0.955 | 5.30 (4.50) | 0.239 | -6.57 (4.57) | 0.151 | -2.76 (4.61) | 0.550 | -5.60 (3.95) | 0.156 |
†Adjusted by age, BMI ≥ 25 kg/m2, LDL-C, Log-TGs, smoking status and ALDH2 genotype. ‡Adjusted by HDL-C age, BMI ≥ 25 kg/m2, LDL-C, Log-TGs, smoking status and ALDH2 genotype. §P values for trend. §§P values for trend in HDL-C levels with drinking habit categories among the carriers of ALDH2 ＊1/＊1 genotype and those of ＊2 allele were 0.010 and 0.002, respectively. §§§P values for trend in CEC levels with drinking habit categories among the carriers of ALDH2 ＊1/＊1 genotype and those of ＊2 allele were 0.134 and 0.086, respectively. || Significance disappeared after Bonferroni’s correction.
HDL-C, high-density lipoprotein cholesterol; CEC, cholesterol efflux capacity; B, unstandardized regression coefficients; SE, standard error; ALDH2, aldehyde dehydrogenase; BMI, body mass index; LDL-C, low-density lipoprotein cholesterol; TGs, triglycerides.