TABLE F.1.
Of results of relationship between the latent classes with other NPI items.
| NPIA—Delusions | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| L‐study | ADNI | |||||||||
| Distal prob | EST | SE | WALD STATI∼S | P | DISTAL PROB | EST | SE | WALD STATI∼S | TYPE | |
| No symptoms | 0.39 | 0.14 | ||||||||
| Combined apa/dep | 0.56 | 0.25 | ||||||||
| Depression | 0.54 | 0.2 | ||||||||
| Apathy | 0.23 | 0.04 | ||||||||
| Combined vs. no symptoms | 0.7 | 0.33 | 4.43 | 0.04 | 0.74 | 0.43 | 2.95 | 0.09 | ||
| Depression vs. no symptoms | 0.63 | 0.44 | 2.08 | 0.15 | 0.44 | 0.51 | 0.73 | 0.39 | ||
| Apathy vs. no symptoms | −0.77 | 0.31 | 6.02 | 0.01 | −1.31 | 0.73 | 3.24 | 0.07 | ||
| Combined vs. depression | 0.07 | 0.49 | 0.02 | 0.89 | 0.3 | 0.52 | 0.33 | 0.57 | ||
| Combined vs. apathy | 1.47 | 0.4 | 13.55 | <0.01 | 2.05 | 0.76 | 7.27 | 0.01 | ||
| Depression vs. apathy | 1.41 | 0.47 | 8.87 | <0.01 | 1.75 | 0.78 | 4.97 | 0.03 | ||
| Omnibus_Test | 16.49 | <0.01 | 8.3 | 0.04 | ||||||
| NPIB—Hallucinations | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| L‐study | ADNI | |||||||||
| DISTAL_PROB | EST | SE | WALD_STATI∼S | P | DISTAL_PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.15 | 0.1 | ||||||||
| Combined apa/dep | 0.36 | 0.17 | ||||||||
| Depression | 0.38 | 0.02 | ||||||||
| Apathy | 0.22 | 0.06 | ||||||||
| Combined vs. no symptoms | 1.16 | 0.38 | 9.49 | 0 | 0.51 | 0.5 | 1.04 | 0.31 | ||
| Depression vs. no symptoms | 1.23 | 0.48 | 6.67 | 0.01 | −1.57 | 1.22 | 1.66 | 0.2 | ||
| Apathy vs. no symptoms | 0.48 | 0.35 | 1.87 | 0.17 | −0.55 | 0.64 | 0.75 | 0.39 | ||
| Combined vs. depression | −0.07 | 0.5 | 0.02 | 0.88 | 2.09 | 1.24 | 2.82 | 0.09 | ||
| Combined vs. apathy | 0.68 | 0.4 | 2.82 | 0.09 | 1.06 | 0.68 | 2.43 | 0.12 | ||
| Depression vs. apathy | 0.75 | 0.48 | 2.49 | 0.11 | −1.02 | 1.29 | 0.63 | 0.43 | ||
| Omnibus_Test | 12.28 | 0.01 | 4.36 | 0.22 | ||||||
| NPIC—Agitation | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| L‐study | ADNI | |||||||||
| DISTAL_PROB | EST | SE | WALD_STATI∼S | P | DISTAL_PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.52 | 0.25 | ||||||||
| Combined apa/dep | 0.8 | 0.4 | ||||||||
| Depression | 0.64 | 0.4 | ||||||||
| Apathy | 0.72 | 0.38 | ||||||||
| Combined vs. no symptoms | 1.34 | 0.39 | 11.53 | 0 | 0.71 | 0.36 | 3.82 | 0.05 | ||
| Depression vs. no symptoms | 0.5 | 0.45 | 1.24 | 0.27 | 0.7 | 0.41 | 2.87 | 0.09 | ||
| Apathy vs. no symptoms | 0.86 | 0.29 | 8.8 | 0 | 0.63 | 0.35 | 3.31 | 0.07 | ||
| Combined vs. depression | 0.83 | 0.55 | 2.32 | 0.13 | 0.01 | 0.44 | 0 | 0.98 | ||
| Combined vs. apathy | 0.47 | 0.44 | 1.14 | 0.29 | 0.08 | 0.39 | 0.04 | 0.83 | ||
| Depression vs. apathy | −0.36 | 0.47 | 0.59 | 0.44 | 0.07 | 0.42 | 0.03 | 0.87 | ||
| Omnibus_Test | 17.04 | 0 | 5.73 | 0.13 | ||||||
| NPIE—Anxiety | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| L‐study | ADNI | |||||||||
| DISTAL_PROB | EST | SE | WALD_STATI∼S | P | DISTAL_PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.22 | 0.16 | ||||||||
| Combined apa/dep | 0.7 | 0.59 | ||||||||
| Depression | 0.41 | 0.3 | ||||||||
| Apathy | 0.27 | 0.29 | ||||||||
| Combined vs. no symptoms | 2.14 | 0.38 | 32.4 | 0 | 1.96 | 0.39 | 25.4 | 0 | ||
| Depression vs. no symptoms | 0.91 | 0.46 | 3.95 | 0.05 | 0.77 | 0.46 | 2.83 | 0.09 | ||
| Apathy vs. no symptoms | 0.3 | 0.32 | 0.86 | 0.35 | 0.73 | 0.39 | 3.48 | 0.06 | ||
| Combined vs. depression | 1.23 | 0.51 | 5.8 | 0.02 | 1.19 | 0.46 | 6.67 | 0.01 | ||
| Combined vs. apathy | 1.84 | 0.41 | 20 | 0 | 1.23 | 0.41 | 9.16 | 0 | ||
| Depression vs. apathy | 0.61 | 0.47 | 1.72 | 0.19 | 0.04 | 0.46 | 0.01 | 0.92 | ||
| Omnibus_Test | 33.81 | 0 | 25.74 | 0 | ||||||
| NPIF—Elation | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| L‐study | ADNI | |||||||||
| DISTAL_PROB | EST | SE | WALD_STATI∼S | P | DISTAL_PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.13 | 0.05 | ||||||||
| Combined apa/dep | 0.19 | 0.04 | ||||||||
| Depression | 0.24 | 0.08 | ||||||||
| Apathy | 0.16 | 0.03 | ||||||||
| Combined vs. no symptoms | 0.43 | 0.44 | 0.95 | 0.33 | −0.32 | 0.85 | 0.14 | 0.71 | ||
| Depression vs. no symptoms | 0.74 | 0.53 | 1.96 | 0.16 | 0.4 | 0.77 | 0.27 | 0.6 | ||
| Apathy vs. no symptoms | 0.24 | 0.39 | 0.39 | 0.53 | −0.55 | 0.86 | 0.41 | 0.52 | ||
| Combined vs. depression | −0.32 | 0.58 | 0.29 | 0.59 | −0.72 | 0.96 | 0.56 | 0.45 | ||
| Combined vs. apathy | 0.19 | 0.48 | 0.15 | 0.7 | 0.24 | 1.06 | 0.05 | 0.82 | ||
| Depression vs. apathy | 0.5 | 0.54 | 0.87 | 0.35 | 0.96 | 0.96 | 0.99 | 0.32 | ||
| Omnibus_Test | 2.32 | 0.51 | 1.18 | 0.76 | ||||||
| NPIH—Disinhibition | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| L‐study | ADNI | |||||||||
| DISTAL_PROB | EST | SE | WALD_STATI∼S | P | DISTAL_PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.15 | 0.14 | ||||||||
| Combined apa/dep | 0.31 | 0.3 | ||||||||
| Depression | 0.27 | 0.3 | ||||||||
| Apathy | 0.26 | 0.17 | ||||||||
| Combined vs no symptoms | 0.91 | 0.39 | 5.55 | 0.02 | 1.05 | 0.42 | 6.28 | 0.01 | ||
| Depression vs no symptoms | 0.74 | 0.51 | 2.12 | 0.15 | 1.01 | 0.47 | 4.59 | 0.03 | ||
| Apathy vs. no symptoms | 0.68 | 0.34 | 3.9 | 0.05 | 0.24 | 0.45 | 0.29 | 0.59 | ||
| Combined vs. depression | −0.17 | 0.54 | 0.1 | 0.75 | 0.04 | 0.47 | 0.01 | 0.94 | ||
| Combined vs. apathy | −0.23 | 0.4 | 0.33 | 0.57 | 0.81 | 0.47 | 2.99 | 0.08 | ||
| Depression vs. apathy | −0.06 | 0.5 | 0.02 | 0.9 | 0.77 | 0.49 | 2.43 | 0.12 | ||
| Omnibus_Test | 7.08 | 0.07 | 8.51 | 0.04 | ||||||
| NPII—Irritability | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| L‐study | ADNI | |||||||||
| DISTAL_PROB | EST | SE | WALD_STATI∼S | P | DISTAL_PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.38 | 0.25 | ||||||||
| Combined apa/dep | 0.69 | 0.51 | ||||||||
| Depression | 0.68 | 0.45 | ||||||||
| Apathy | 0.47 | 0.29 | ||||||||
| Combined vs. no symptoms | 1.27 | 0.35 | 12.97 | 0 | 1.19 | 0.36 | 10.92 | 0 | ||
| Depression vs. no symptoms | 1.24 | 0.47 | 6.96 | 0.01 | 0.91 | 0.41 | 4.92 | 0.03 | ||
| Apathy vs. no symptoms | 0.33 | 0.28 | 1.43 | 0.23 | 0.2 | 0.36 | 0.3 | 0.58 | ||
| Combined vs. depression | 0.03 | 0.53 | 0 | 0.96 | 0.29 | 0.43 | 0.43 | 0.51 | ||
| Combined vs. apathy | 0.93 | 0.39 | 5.84 | 0.02 | 0.99 | 0.4 | 6.01 | 0.01 | ||
| Depression vs. apathy | 0.91 | 0.48 | 3.61 | 0.06 | 0.71 | 0.43 | 2.68 | 0.1 | ||
| Omnibus_Test | 16.92 | 0 | 13.27 | 0 | ||||||
| NPIJ—AMB | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| L‐study | ADNI | |||||||||
| DISTAL_PROB | EST | SE | WALD_STATI∼S | P | DISTAL_PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.3 | 0.17 | ||||||||
| Combined apa/dep | 0.32 | 0.31 | ||||||||
| Depression | 0.19 | 0.2 | ||||||||
| Apathy | 0.41 | 0.38 | ||||||||
| Combined vs. no symptoms | 0.07 | 0.35 | 0.04 | 0.85 | 1.07 | 0.39 | 7.47 | 0.01 | ||
| Depression vs. no symptoms | −0.61 | 0.55 | 1.23 | 0.27 | 0.21 | 0.5 | 0.18 | 0.67 | ||
| Apathy vs. no symptoms | 0.46 | 0.29 | 2.52 | 0.11 | 0.8 | 0.38 | 4.43 | 0.04 | ||
| Combined vs. depression | 0.68 | 0.59 | 1.3 | 0.25 | 0.86 | 0.51 | 2.84 | 0.09 | ||
| Combined vs. apathy | −0.39 | 0.39 | 1.02 | 0.31 | 0.27 | 0.41 | 0.43 | 0.51 | ||
| Depression vs. apathy | −1.07 | 0.55 | 3.75 | 0.05 | −0.59 | 0.49 | 1.42 | 0.23 | ||
| Omnibus_Test | 4.99 | 0.17 | 9.33 | 0.03 | ||||||
| NPIK—Sleep and night time | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| L‐study | ADNI | |||||||||
| DISTAL_PROB | EST | SE | WALD_STATI∼S | P | DISTAL_PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.22 | 0.16 | ||||||||
| Combined apa/dep | 0.34 | 0.42 | ||||||||
| Depression | 0.27 | 0.35 | ||||||||
| Apathy | 0.33 | 0.32 | ||||||||
| Combined vs. no symptoms | 0.63 | 0.36 | 3.01 | 0.08 | 1.27 | 0.39 | 10.45 | 0 | ||
| Depression vs. no symptoms | 0.29 | 0.5 | 0.34 | 0.56 | 1.03 | 0.45 | 5.34 | 0.02 | ||
| Apathy vs. no symptoms | 0.6 | 0.31 | 3.72 | 0.05 | 0.91 | 0.38 | 5.58 | 0.02 | ||
| Combined vs. depression | 0.34 | 0.54 | 0.4 | 0.53 | 0.23 | 0.45 | 0.27 | 0.6 | ||
| Combined vs. apathy | 0.03 | 0.39 | 0.01 | 0.94 | 0.36 | 0.4 | 0.81 | 0.37 | ||
| Depression vs. apathy | −0.31 | 0.5 | 0.39 | 0.53 | 0.13 | 0.44 | 0.09 | 0.77 | ||
| Omnibus_Test | 5.05 | 0.17 | 11.93 | 0.01 | ||||||
| NPIL—Eating | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| L‐study | ADNI | |||||||||
| DISTAL_PROB | EST | SE | WALD_STATI∼S | P | DISTAL_PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.19 | 0.22 | ||||||||
| Combined apa/dep | 0.29 | 0.47 | ||||||||
| Depression | 0.27 | 0.32 | ||||||||
| Apathy | 0.3 | 0.41 | ||||||||
| Combined vs. no symptoms | 0.52 | 0.38 | 1.9 | 0.17 | 1.09 | 0.37 | 8.83 | 0 | ||
| Depression vs. no symptoms | 0.44 | 0.5 | 0.77 | 0.38 | 0.5 | 0.43 | 1.34 | 0.25 | ||
| Apathy vs. no symptoms | 0.6 | 0.32 | 3.52 | 0.06 | 0.89 | 0.35 | 6.55 | 0.01 | ||
| Combined vs. depression | 0.08 | 0.54 | 0.02 | 0.88 | 0.59 | 0.45 | 1.7 | 0.19 | ||
| Combined vs. apathy | −0.08 | 0.4 | 0.04 | 0.84 | 0.19 | 0.39 | 0.25 | 0.62 | ||
| Depression vs. apathy | −0.16 | 0.5 | 0.11 | 0.74 | −0.4 | 0.43 | 0.84 | 0.36 | ||
| Omnibus_Test | 4.13 | 0.25 | 11.11 | 0.01 | ||||||
Abbreviations: ADNI, Alzheimer's Disease Neuroimaging Initiative; L‐study, Measuring Long Term Outcomes in People with Dementia in Care Homes; NPI, Neuropsychiatric Inventory; SE, standard error.