TABLE G.1.
Of results of relationship between the latent classes with other clinically significant NPI symptoms.
| NPIA—Delusions | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CHRN | ADNI | |||||||||
| DISTAL PROB | EST | SE | WALD_STATI∼S | P | DISTAL PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.24 | 0.05 | ||||||||
| Combined apa/dep | 0.33 | 0.12 | ||||||||
| Depression | 0.34 | 0.10 | ||||||||
| Apathy | 0.13 | 0.03 | ||||||||
| Combined vs. no symptoms | 0.45 | 0.36 | 1.60 | 0.21 | 0.89 | 0.62 | 2.03 | 0.15 | ||
| Depression vs. no symptoms | 0.48 | 0.47 | 1.07 | 0.30 | 0.72 | 0.72 | 0.99 | 0.32 | ||
| Apathy vs. no symptoms | −0.74 | 0.38 | 3.79 | 0.05 | −0.60 | 0.90 | 0.44 | 0.51 | ||
| Combined vs. depression | −0.03 | 0.51 | 0.00 | 0.95 | 0.17 | 0.95 | 1.92 | 0.81 | ||
| Combined vs. apathy | 1.19 | 0.46 | 6.80 | 0.01 | 1.48 | 0.92 | 2.63 | 0.10 | ||
| Depression vs. apathy | 1.22 | 0.52 | 5.48 | 0.02 | 1.32 | 0.70 | 0.06 | 0.17 | ||
| Omnibus_Test | 8.43 | 0.04 | 3.86 | 0.28 | ||||||
| NPIB—Hallucinations | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CHRN | ADNI | |||||||||
| DISTAL PROB | EST | SE | WALD_STATI∼S | P | DISTAL PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.08 | 0.01 | ||||||||
| Combined apa/dep | 0.17 | 0.06 | ||||||||
| Depression | 0.28 | 0.02 | ||||||||
| Apathy | 0.09 | 0.03 | ||||||||
| Combined vs. no symptoms | 0.89 | 0.49 | 3.34 | 0.07 | 2.00 | 1.26 | 2.53 | 0.11 | ||
| Depression vs. no symptoms | 1.51 | 0.55 | 7.54 | 0.01 | 1.10 | 1.60 | 0.48 | 0.49 | ||
| Apathy vs. no symptoms | 0.10 | 0.50 | 0.04 | 0.85 | 1.32 | 1.34 | 0.97 | 0.33 | ||
| Combined vs. depression | −0.62 | 0.57 | 1.17 | 0.28 | 0.90 | 1.23 | 0.53 | 0.47 | ||
| Combined vs. apathy | 0.79 | 0.56 | 2.04 | 0.15 | 0.68 | 0.98 | 0.48 | 0.49 | ||
| Depression vs. apathy | 1.41 | 0.58 | 5.98 | 0.01 | −0.22 | 1.30 | 0.03 | 0.87 | ||
| Omnibus_Test | 9.70 | 0.02 | 2.75 | 0.43 | ||||||
| NPIC—Agitation | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CHRN | ADNI | |||||||||
| DISTAL PROB | EST | SE | WALD_STATI∼S | P | DISTAL PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.28 | 0.06 | ||||||||
| Combined apa/dep | 0.53 | 0.19 | ||||||||
| Depression | 0.33 | 0.10 | ||||||||
| Apathy | 0.44 | 0.07 | ||||||||
| Combined vs. no symptoms | 1.09 | 0.34 | 10.33 | 0.00 | 1.32 | 0.54 | 5.90 | 0.02 | ||
| Depression vs. no symptoms | 0.27 | 0.47 | 0.35 | 0.56 | 0.53 | 0.71 | 0.57 | 0.45 | ||
| Apathy vs. no symptoms | 0.71 | 0.29 | 6.01 | 0.01 | 0.23 | 0.64 | 0.12 | 0.72 | ||
| Combined vs. depression | 0.82 | 0.51 | 2.61 | 0.11 | 0.79 | 0.66 | 1.42 | 0.23 | ||
| Combined vs. apathy | 0.38 | 0.37 | 1.09 | 0.30 | 1.09 | 0.62 | 3.12 | 0.08 | ||
| Depression vs. apathy | −0.43 | 0.47 | 0.86 | 0.35 | 0.31 | 0.74 | 0.17 | 0.68 | ||
| Omnibus_Test | 12.86 | 0.00 | 6.74 | 0.08 | ||||||
| NPIE—Anxiety | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CHRN | ADNI | |||||||||
| DISTAL PROB | EST | SE | WALD_STATI∼S | P | DISTAL PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.13 | 0.04 | ||||||||
| Combined apa/dep | 0.46 | 0.25 | ||||||||
| Depression | 0.20 | 0.20 | ||||||||
| Apathy | 0.18 | 0.04 | ||||||||
| Combined vs. no symptoms | 1.72 | 0.38 | 20.65 | 0.00 | 2.11 | 0.62 | 11.58 | 0.00 | ||
| Depression vs. no symptoms | 0.52 | 0.56 | 0.86 | 0.35 | 1.81 | 0.70 | 6.73 | 0.01 | ||
| Apathy vs. no symptoms | 0.37 | 0.38 | 0.93 | 0.34 | 0.07 | 0.86 | 0.01 | 0.94 | ||
| Combined vs. depression | 1.20 | 0.57 | 4.52 | 0.03 | 0.30 | 0.52 | 0.32 | 0.57 | ||
| Combined vs. apathy | 1.35 | 0.42 | 10.58 | 0.00 | 2.04 | 0.76 | 7.28 | 0.01 | ||
| Depression vs. apathy | 0.15 | 0.56 | 0.07 | 0.79 | 1.75 | 0.78 | 5.00 | 0.03 | ||
| Omnibus_Test | 21.70 | 0.00 | 16.04 | 0.00 | ||||||
| NPIF—Elation | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CHRN | ADNI | |||||||||
| DISTAL PROB | EST | SE | WALD_STATI∼S | P | DISTAL PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.08 | 0.04 | ||||||||
| Combined apa/dep | 0.03 | 0.00 | ||||||||
| Depression | 0.07 | 0.00 | ||||||||
| Apathy | 0.04 | 0.00 | ||||||||
| Combined vs. no symptoms | −0.94 | 0.85 | 1.23 | 0.27 | −10.80 | 0.17 | 3963.30 | 0.00 | ||
| Depression vs. no symptoms | −0.21 | 0.87 | 0.06 | 0.81 | −31.26 | ### | 0.00 | 1.00 | ||
| Apathy vs. no symptoms | −0.74 | 0.62 | 1.40 | 0.24 | −31.26 | ### | 0.00 | 1.00 | ||
| Combined vs. depression | −0.72 | 1.13 | 0.41 | 0.52 | 20.46 | ### | 0.00 | 1.00 | ||
| Combined vs. apathy | −0.20 | 0.99 | 0.04 | 0.84 | 20.46 | ### | 0.00 | 1.00 | ||
| Depression vs. apathy | 0.53 | 0.96 | 0.31 | 0.58 | 0.00 | ### | 0.00 | 1.00 | ||
| Omnibus_Test | 2.37 | 0.50 | 3963.30 | 0.00 | ||||||
| NPIH—Disinhibition | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CHRN | ADNI | |||||||||
| DISTAL PROB | EST | SE | WALD_STATI∼S | P | DISTAL PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.06 | 0.03 | ||||||||
| Combined apa/dep | 0.15 | 0.06 | ||||||||
| Depression | 0.21 | 0.13 | ||||||||
| Apathy | 0.14 | 0.01 | ||||||||
| Combined vs. no symptoms | 0.96 | 0.53 | 3.36 | 0.07 | 0.61 | 0.83 | 0.54 | 0.46 | ||
| Depression vs. no symptoms | 1.34 | 0.61 | 4.92 | 0.03 | 1.47 | 0.78 | 3.52 | 0.06 | ||
| Apathy vs. no symptoms | 0.86 | 0.47 | 3.32 | 0.07 | −0.83 | 1.24 | 0.44 | 0.51 | ||
| Combined vs. depression | −0.38 | 0.62 | 0.38 | 0.54 | −0.86 | 0.78 | 1.23 | 0.27 | ||
| Combined vs. apathy | 0.10 | 0.51 | 0.04 | 0.84 | 1.43 | 1.28 | 1.26 | 0.26 | ||
| Depression vs. apathy | 0.49 | 0.57 | 0.74 | 0.39 | 2.29 | 1.20 | 3.63 | 0.06 | ||
| Omnibus_Test | 6.27 | 0.10 | 5.64 | 0.13 | ||||||
| NPII—Irritability | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CHRN | ADNI | |||||||||
| DISTAL PROB | EST | SE | WALD_STATI∼S | P | DISTAL PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.21 | 0.05 | ||||||||
| Combined apa/dep | 0.40 | 0.21 | ||||||||
| Depression | 0.41 | 0.28 | ||||||||
| Apathy | 0.24 | 0.15 | ||||||||
| Combined vs. no symptoms | 0.91 | 0.35 | 6.56 | 0.01 | 1.54 | 0.57 | 7.33 | 0.01 | ||
| Depression vs. no symptoms | 0.97 | 0.46 | 4.46 | 0.03 | 1.89 | 0.61 | 9.77 | 0.00 | ||
| Apathy vs. no symptoms | 0.19 | 0.33 | 0.34 | 0.56 | 1.14 | 0.58 | 3.89 | 0.05 | ||
| Combined vs. depression | −0.06 | 0.49 | 0.01 | 0.90 | −0.36 | 0.50 | 0.50 | 0.48 | ||
| Combined vs. apathy | 0.72 | 0.39 | 3.30 | 0.07 | 0.40 | 0.50 | 0.63 | 0.43 | ||
| Depression vs. apathy | 0.78 | 0.47 | 2.75 | 0.10 | 0.76 | 0.51 | 2.22 | 0.14 | ||
| Omnibus_Test | 9.10 | 0.03 | 10.78 | 0.01 | ||||||
| NPIJ—AMB | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CHRN | ADNI | |||||||||
| DISTAL PROB | EST | SE | WALD_STATI∼S | P | DISTAL PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.24 | 0.08 | ||||||||
| Combined apa/dep | 0.32 | 0.25 | ||||||||
| Depression | 0.12 | 0.15 | ||||||||
| Apathy | 0.31 | 0.20 | ||||||||
| Combined vs. no symptoms | 0.41 | 0.36 | 1.32 | 0.25 | 1.39 | 0.49 | 8.05 | 0.00 | ||
| Depression vs. no symptoms | −0.81 | 0.65 | 1.52 | 0.22 | 0.74 | 0.61 | 1.49 | 0.22 | ||
| Apathy vs. no symptoms | 0.34 | 0.31 | 1.27 | 0.26 | 1.10 | 0.49 | 5.02 | 0.03 | ||
| Combined vs. depression | 1.22 | 0.69 | 3.16 | 0.08 | 0.65 | 0.57 | 1.32 | 0.25 | ||
| Combined vs. apathy | 0.07 | 0.39 | 0.03 | 0.86 | 0.30 | 0.46 | 0.41 | 0.52 | ||
| Depression vs. apathy | −1.15 | 0.65 | 3.09 | 0.08 | −0.35 | 0.56 | 0.40 | 0.53 | ||
| Omnibus_Test | 4.68 | 0.20 | 8.89 | 0.03 | ||||||
| NPIK—Sleep and night time | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CHRN | ADNI | |||||||||
| DISTAL PROB | EST | SE | WALD_STATI∼S | P | DISTAL PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.12 | 0.06 | ||||||||
| Combined apa/dep | 0.30 | 0.27 | ||||||||
| Depression | 0.17 | 0.25 | ||||||||
| Apathy | 0.18 | 0.23 | ||||||||
| Combined vs. no symptoms | 1.09 | 0.40 | 7.38 | 0.01 | 1.84 | 0.55 | 11.32 | 0.00 | ||
| Depression vs. no symptoms | 0.36 | 0.60 | 0.36 | 0.55 | 1.74 | 0.61 | 8.18 | 0.00 | ||
| Apathy vs. no symptoms | 0.41 | 0.39 | 1.13 | 0.29 | 1.63 | 0.54 | 9.07 | 0.00 | ||
| Combined vs. depression | 0.73 | 0.61 | 1.44 | 0.23 | 0.10 | 0.49 | 0.04 | 0.84 | ||
| Combined vs. apathy | 0.68 | 0.43 | 2.47 | 0.12 | 0.21 | 0.44 | 0.22 | 0.64 | ||
| Depression vs. apathy | −0.05 | 0.59 | 0.01 | 0.93 | 0.11 | 0.48 | 0.05 | 0.82 | ||
| Omnibus_Test | 7.43 | 0.06 | 12.68 | 0.01 | ||||||
| NPIL—eating | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CHRN | ADNI | |||||||||
| DISTAL PROB | EST | SE | WALD_STATI∼S | P | DISTAL PROB | EST | SE | WALD_STATI∼S | P | |
| No symptoms | 0.14 | 0.17 | ||||||||
| Combined apa/dep | 0.22 | 0.35 | ||||||||
| Depression | 0.13 | 0.25 | ||||||||
| Apathy | 0.25 | 0.35 | ||||||||
| Combined vs. no symptoms | 0.56 | 0.42 | 1.79 | 0.18 | 0.93 | 0.39 | 5.64 | 0.02 | ||
| Depression vs. no symptoms | −0.06 | 0.64 | 0.01 | 0.93 | 0.46 | 0.47 | 0.96 | 0.33 | ||
| Apathy vs. no symptoms | 0.74 | 0.35 | 4.47 | 0.03 | 0.97 | 0.37 | 6.76 | 0.01 | ||
| Combined vs. depression | 0.62 | 0.68 | 0.83 | 0.36 | 0.47 | 0.48 | 0.95 | 0.33 | ||
| Combined vs. apathy | −0.18 | 0.43 | 0.17 | 0.68 | −0.04 | 0.40 | 0.01 | 0.93 | ||
| Depression vs. apathy | −0.80 | 0.63 | 1.59 | 0.21 | −0.51 | 0.46 | 1.21 | 0.27 | ||
| Omnibus_Test | 5.56 | 0.14 | 8.83 | 0.03 | ||||||
Abbreviations: ADNI, Alzheimer's Disease Neuroimaging Initiative; CHRN, Care Home Research Network; L‐study, Measuring Long Term Outcomes in People with Dementia in Care Homes; NPI, Neuropsychiatric Inventory; SE, standard error.