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. 2023 Feb 5;13:2069. doi: 10.1038/s41598-022-22841-6

Table 3.

Associations of heavy cannabis users* and blood pressure levels among men, using linear regression models.

Men SBP DBP PP
Parameters Age adjusted Estimated difference Covariate adjusted Estimated difference Interaction** Age adjusted Estimated difference Covariate adjusted Estimated difference Interaction** Age adjusted Estimated difference Covariate adjusted Estimated difference Interaction**
Current smokers − 2.76 (0.64)  < 0.001 − 2.25 (0.63)  < 0.001 0.843 − 1.45 (0.35)  < 0.001 − 1.00 (0.40) 0.003 0.513 − 1.30 (0.43) 0.003 − 1.24 (0.44) 0.005 0.563
No current smokers − 0.95 (0.31) 0.002 − 0.95 (0.31) 0.002 − 0.52 (0.17) 0.002 − 0.46 (0.16) 0.004 − 0.43 (0.22) 0.048 − 0.49 (0.22) 0.026
Alcohol 0.263 0.003 0.813
High − 1.67 (0.48)  < 0.001 − 1.56 (0.48)  < 0.001 − 0.97 (0.24)  < 0.001 − 0.78 (0.24) 0.001 − 0.69 (0.33) 0.039 − 0.78 (0.34) 0.020
Moderate − 1.10 (0.37) 0.003 − 0.77 (0.37) 0.034 − 0.57 (0.19) 0.004 − 0.31 (0.19) 0.099 − 0.53 (0.26) 0.038 − 0.45 (0.25) 0.079
Low − 1.61 (0.92) 0.081 − 1.18 (0.91) 0.193 − 1.19 (0.51) 0.019 − 0.73 (0.48) 0.134 − 0.42 (0.66) 0.519 − 0.46 (0.66) 0.490
Income 0.346 0.998 0.022
High − 1.05 (0.40) 0.008 − 0.86 (0.40) 0.029 − 0.56 (0.22) 0.011 − 0.42 (0.21) 0.047 − 0.50 (0.27) 0.058 − 0.43 (0.27) 0.019
Moderate − 1.34 (0.43) 0.002 − 1.03 (0.42) 0.014 − 0.77 (0.22)  < 0.001 − 0.50 (0.21) 0.020 − 0.56 (0.30) 0.061 − 0.53 (0.30) 0.077
Low − 1.93 (0.89) 0.031 − 1.73 (0.90) 0.053 − 1.00 (0.46) 0.030 − 0.81 (0.45) 0.071 − 0.93 (0.63) 0.141 − 0.91 (0.64) 0.154
Education 0.720 0.565 0.897
High − 1.22 (0.36)  < 0.001 − 1.15 (0.35) 0.001 − 0.55 (0.19) 0.005 − 0.44 (0.19) 0.019 − 0.67 (0.25) 0.006 − 0.72 (0.24) 0.004
Moderate − 1.09 (0.51) 0.032 − 0.81 (0.51) 0.107 − 0.83 (0.27) 0.002 − 0.57 (0.26) 0.030 − 0.26 (0.36) 0.470 − 0.24 (0.36) 0.053
Low − 1.81 (0.81) 0.033 − 1.55 (0.85) 0.068 − 1.05 (0.44) 0.017 − 0.66 (0.43) 0.128 − 0.76 (0.61) 0.212 − 0.89 (0.61) 0.148
Diabetes − 1.59 (1.58) 0.316 − 1.54 (1.61) 0.334 0.986 − 0.40 (0.83) 0.631 − 0.46(0.81) 0.576 0.357 − 1.19 (1.20) 0.319 − 1.09 (1.21) 0.369 0.662
No diabetes − 1.25 (0.28)  < 0.001 − 1.06 (0.24) 0.472 − 0.79 (0.15)  < 0.001 − 0.49 (0.15)  < 0.001 − 0.55 (0.19) 0.005 − 0.47 (0.19) 0.004
Dyslipidemia − 1.13 (0.37) 0.002 − 0.88 (0.37) 0.018 0.019 − 0.72 (0.19)  < 0.001 − 0.42 (0.19) 0.029 0.004 − 0.42 (0.26) 0.113 − 0.45 (0.26) 0.085 0.298
No dyslipidemia − 1.46 (0.41)  < 0.001 − 1.37 (0.41)  < 0.001 − 0.71 (0.22) 0.001 − 0.62 (0.23) 0.004 − 0.77 (0.28) 0.007 − 0.74 (0.29) 0.010
BMI 0.553 0.159 0.913
High − 0.15 (0.48) 0.763 − 0.18 (0.76) 0.817 − 0.14 (0.40) 0.735 − 0.07 (0.40) 0.861 − 0.03 (0.54) 0.954 − 0.11 (0.45) 0.844
Moderate − 0.78 (0.25) 0.002 − 1.17 (0.39) 0.003 − 0.61 (0.21) 0.003 − 0.61 (0.21) 0.003 − 0.52 (0.28) 0.067 − 0.55 (0.28) 0.049
Low − 0.57 (0.27) 0.037 − 1.37 (0.44) 0.002 − 0.36 (0.22) 0.108 − 0.52 (0.23) 0.021 − 0.64 (0.30) 0.035 − 0.84 (0.31) 0.006

SBP systolic blood pressure, DBP diastolic blood pressure, PP pulse pressure, BMI body mass index.

*Referent group is never user of cannabis.

**Interaction were performed among covariate adjusted models.

Covariates adjusted estimated differences were adjusted for age, education, income level, tobacco habits, alcohol consumption, BMI categories, dyslipidemia, and diabetes, except for the stratified variables.