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. 2023 Jan 23;14:1094020. doi: 10.3389/fphar.2023.1094020

FIGURE 1.

FIGURE 1

The elements of the endocannabinoid system and receptors distribution. ECS is composed of its two main endocannabinoids AEA and 2-AG, which activate their primary targets CB1 and CB2. AEA was degraded by FAAH enzyme and 2-AG by MAGL enzyme. Six plant cannabinoids (phytocannabinoids), Δ9-THC, CBC, CBNV, CBN, CBE, and CBD, and of five synthetic cannabinoids, JWH015, Arvanil, WIN55212-2, CP47/497, HU-210. CB1 receptors are mainly distributed in the central nervous system and the surface of neurocyte. CB2 receptors are mainly distributed in the peripheral immune system and on the surface of immune cells, such as CD4+T cells, CD8+T cells, macrophages and dendritic cells. AEA, arachidonoylethanolamine; 2-AG, 2-arachidonoylglycerol; Δ9-THC, Δ9-tetrahydrocannabinol; CB1/2, cannabinoid receptor1/2; CBC, cannabichromene; CBD, cannabidiol; CBE, cannabielsoin; CBN, cannabinol; CBNV, cannabinolivarin; ECS, endocannabinoid system; FAAH, fatty acid amide hydrolase; MAGL, monoacylglycerol lipase.