TABLE 6.
p53 mutational landscape.
| p53 mutational status | No. | ClinVar ID | Functional consequence |
| Wild-type | 22 | ||
| Mutated | 31 | ||
| p.Arg175His | 4 | 12374 | GOF |
| p.Cys135Tyr | 4 | 141762 | LOF |
| p.Gln100Ter and p.Pro72Arg | 2 | 634707 | LOF |
| p.Glu286Lys and p.Pro72Arg | 1 | 183752 | LOF |
| p.Arg273His | 1 | 12366 | GOF |
| p.Val173Ala | 1 | 376017 | LOF |
| p.Arg306Ter and Pro72Arg | 1 | 142144 | LOF |
| p.Arg65Ter and p.Pro72Arg | 1 | 634670 | LOF |
| p.Arg213Ter | 1 | 43590 | LOF |
| p.Arg175His and p.Pro72Arg | 1 | 12374 | LOF |
| p.Arg306Ter | 1 | 142144 | LOF |
| p.Arg196Ter | 1 | 43589 | LOF |
| p.Arg248Trp and p.Pro72Arg | 1 | 12347 | GOF |
| p.Arg273Cys | 1 | 43594 | LOF |
| p.Arg248Gln | 1 | 12356 | GOF |
| p.Cys38Phe and p.Pro72Arg | 1 | Not present | Not reported |
| p.Cys135Phe | 1 | 376559 | LOF |
| p.Gly245Ser | 1 | 12365 | GOF |
| p.Gly108ValfsTer15 | 1 | Not present | Not reported |
| p.Gly244Cys | 1 | 376599 | LOF |
| p.Ile195Thr | 1 | 216077 | LOF |
| p.Pro152Leu | 1 | 142766 | LOF |
| p.Ser24Phe | 1 | Not present | Not reported |
| p.Tyr220Cys | 1 | 127819 | LOF |
GOF, gain of function; LOS, loss of function; Ter, termination codon.