Table 1.

Selected features.

Feature type	Feature	Feature description
Clinical feature	Age	Age at Baseline of IO
	Sex	Sex: female (0) or male (1)
	Smoke	Smoking status: non-smoker (0) or smoker (1)
	ECOG PS	ECOG Performance Status, from 0 to 5, where 0 is the best and 5 the worst status (dead)
	BMI	BMI at the Baseline of IO
Radiological	Liver mets	Liver Metastasis at Baseline of IO
	Brain mets	Brain Metastasis at Baseline of IO
	Bone mets	Bone Metastasis at Baseline of IO
	Lymph nodes mets	Lymph nodes Metastasis at Baseline of IO
	Adrenal mets	Adrenal Metastasis at Baseline of IO
	Pleura mets	Pleura Metastasis at Baseline of IO
Laboratory exams	ALC	Absolut Leukocytes count at baseline of IO
	ANC	Absolute Neutrophils count at baseline of IO
	AMC	Absolute Monocytes count at baseline of IO
	ALyC	Absolute Lymphocytes count at baseline of IO
	NLR	Neutrophils to Lymphocytes ratio at baseline of IO
	LDH	Lactate Dehydrogenase at baseline of IO
Staging	TNMd	TNM staging at diagnosis
	TNMio	TNM staging at baseline of IO
	T	Tumor Stage at Baseline of IO
	N	Node Stage at baseline of IO
Treatment information	IO/IOCT	Indicates if a patient received just Immunotherapy (0) or Immunotherapy with Chemotherapy (1)
	Nr Line IO	Number line of IO
	Surgery	Surgery (0 = No, 1= Yes)
	RT	Radiotherapy prior IO
Tumor characteristic	Histology	Indicates if the tumor type is Squamous (1) or not (0)
	PDL1	Value of PD-L1 divided in 3 classes:>1 (1), 1>PD-L1<49 (2) and ≥50 (3)