Table 6.

List of the most important features for DCR, OS6 and TTF3.

Outcomes	Model	1	2	3	4	5	6
DCR Class 0: PD Class 1: SD+PR+CR	CatBoost	NLR	IO/IOCT	Line of IO	LDH	Age	PD-L1
	Logistic Regression	IO/IOCT	PD-L1	NLR	TNMio	ECOG PS	RT
OS6 Class 0/1: <6/≥6 months	CatBoost	ECOG PS	NLR	ANC	TNMio	LDH	AMC
	Logistic Regression	ECOG PS	Line of IO	TNMio	NLR	Histology	AMC
TTF3 Class 0/1: <3/≥3 months	CatBoost	NLR	ECOG PS	TNMio	IO/IOCT	AMC	LDH
	Logistic Regression	NLR	IO/IOCT	ECOG PS	PD-L1	TNMio	AMC

IO/IOCT, Immunotherapy alone vs chemo-immunotherapy combination.

The position of the features from 1 to 6 is determined based on the most important feature in terms of Shap Value. The red color is assigned to those features where a high value led to a negative correlation with DCR, OS6 or TTF3 (Red high value (Class 0); Green color is assigned to those features in which a high value positively correlates with DCR and OS6 (Green high value (Class 1). For IO/IOCT, the high value means the chemo and IO combination therapy.