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. 2023 Jan 23;10:1117816. doi: 10.3389/fmed.2023.1117816

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Copyright © 2023 Machiraju, Schäfer, Beckhove, Roth, Schulz and Hassel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rapid disease progression on immune checkpoint inhibitors (ICIs) in young patients with stage IV cutaneous melanoma. Kaplan Meier curves based on age groups for (A) progression-free survival and (B) overall survival. (C) The forest plot indicates univariate (box symbol) and multivariate regression (star symbol) analysis for PFS of ICI-treated mCM patients. The green color in the plot indicates that this clinical feature is a high-risk factor for PFS in univariate analysis, and the bright red indicates a high-risk factor in the multivariate model. P-values from the multivariate analysis are presented on the graph.