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Pathologic STAT5B mutations identified in patients. The STAT5b domains and amino acids residue positions are indicated. Red, homozygous LOF mutations; Purple, dominant-negative LOF mutations with growth hormone insensitivity and eczema; Blue, dominant-negative LOF mutation associated with immune dysregulation lacking growth hormone insensitivity; Green, severe allergic somatic GOF mutation; Black, somatic GOF mutations.
