Table 1.

Simplified treatment strategies in LN and ANCA-associated GN (esp. active, severe GPA/MPA) (62, 63).

	LN	ANCA-associated GN
Induction therapy	Hydroxychloroquine (basic therapy) + Glucocorticoids + Mycophenolate mofetil + Cyclophosphamide	Glucocorticoids + Rituximab or Cyclophosphamide (Plasma exchange)
Maintenance therapy	Hydroxychloroquine (basic therapy) + Mycophenolate mofetil or Azathioprine	Rituximab or Azathioprine
Add-On	Renin-angiotensin-aldosterone system blockers Belimumab (SGLT2 inhibitors)	Renin-angiotensin-aldosterone system blockers Mycophenolate mofetil Avacopan (SGLT2 inhibitors)

Generally, the therapy regimen depends on disease severity and the risk of progression. Moreover, the therapy regimen changes according to the type of ANCA-associated GN.