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. 2023 Jan 23;14:1051606. doi: 10.3389/fimmu.2023.1051606

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Copyright © 2023 Xia, Wang, Yang, Hou, Li, Zhu and Fu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Schematic diagram of the synthesis of the cross-linked HA hydrogel system. (B) Stained NP cell morphology by the LIVE/DEAD assay after 3 days of culture in the presence of hydrogels containing different doses of HA. Live cells are green (calcein staining) and dead cells are red (ethidium bromide staining). (C) Fold changes of NGF and BNDF downregulated in IL-1β-induced inflammation and normal NP cells treated with cross-linked HA hydrogels for 7 days. Reproduced with permission from (46). *Indicates significant difference at a 99 %confidence level.