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. 2023 Feb 1;17:283–295. doi: 10.2147/DDDT.S392813

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© 2023 Yin et al.

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VCM caused obvious renal injury in C57BL/6J mice, while Fer-1 treatment reversed the harmful effects of VCM. (A) The dissected renal tissue was weighed after injection of VCM. After VCM injection, the weight of renal tissue increased. In addition, serum CR and BUN levels in mice were assessed by ELISA. (B) H&E staining (400×) showed that the mice injected with VCM had significantly enlarged lumen areas in the kidney, which were reversed by Fer-1 treatment. (C) PAS staining showed swollen glomerulus with obvious collagen deposition in the kidney tissues of mice injected with VCM. Expression levels of Ki67 and DDX5 in the kidney tissues of mice measured by (D) qRT-PCR analysis, (E) immunohistochemistry staining (200×), (F) Western blotting analysis and (G) quantification of Western blotting results. The results showed that the mRNA and protein levels of Ki67 and DDX5 decreased in the kidney tissues of mice injected with VCM. Moreover, Fer-1 treatment restored the expression of Ki67 and DDX5 at the mRNA and protein levels. ***P<0.001.