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. 2023 Jan 23;13:1082841. doi: 10.3389/fonc.2023.1082841

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Copyright © 2023 Ouyang, Ma, Zhao, Ye, Zhao, Cai, Zhang, Zheng and Lin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Metabolic pathways associated with various metabolic alterations in ESCC vs. HCs. (B, C) Comparison of the metabolic enzyme gene expression related to “glycine, serine and threonine metabolism” between ESCC cancer tissues and normal tissues (ns, p≥0.05; *, p< 0.05; **, p<0.01; ***, p<0.001). (D) Comparison of the ROC curves used for distinguishing ESCC patients from HCs, based on the levels of various individual serum and urine metabolites and a combined set of metabolites. (E) Prediction and validation of the diagnostic accuracy of the optimal combined biomarker panel for ESCC detection (“training set”: ESCC=50, HC=50; “discovery set”: ESCC=20, HC=20). ns, not statistically significant.