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. 2023 Jan 23;13:1082841. doi: 10.3389/fonc.2023.1082841

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Copyright © 2023 Ouyang, Ma, Zhao, Ye, Zhao, Cai, Zhang, Zheng and Lin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Altered metabolic pathways for the most relevant distinguishing metabolites (Red: common changed metabolites in tissue, serum and urine; Purple: changed metabolites in both tissue and serum; Light blue: changed metabolites in both tissue and urine; Yellow: tissue-specific metabolites; Navy: serum-specific metabolites; Green: urine-specific metabolites. Red arrow: increased or decreased with respect to control in tissue; Yellow arrow: increased or decreased with respect to control in serum; Green arrow: increased or decreased with respect to control in urine).