Table 1.
Cohort demographic characteristics at baseline.
| CU Aβ− n = 89 | CU Aβ+ n = 44 | MCI Aβ+ n = 26 | AD Aβ+ n = 25 | |
|---|---|---|---|---|
| Age (yrs) | 74.1 ± 4.5 | 78.8 ± 6.3∗∗ | 74.7 ± 7.8 | 69.4 ± 8.1∗∗ |
| Sex, F (%) | 42 (47.2%) | 24 (54.5%) | 9 (34.6%) | 12 (48.0%) |
| APOE ε4+ (%)a | 26 (29.9%) | 24 (55.8%)∗ | 11 (61.1%)∗ | 10 (62.5%)∗ |
| Centiloid | 4.3 ± 9.0 | 83.1 ± 40.7∗∗ | 94.3 ± 45.3∗∗ | 110.7 ± 32.8∗∗ |
| Baseline MMSE | 28.6 ± 1.2 | 28.1 ± 1.5∗ | 26.4 ± 1.6∗∗ | 22.1 ± 3.4∗∗ |
| Duration of follow-up (yrs) [Median (range)] | 1.56 (0.97, 3.62) | 2.22 (0.96, 3.58) | 1.26 (1.00, 3.53) | 1.32 (0.93, 3.83)∗ |
Mean (SD), unless otherwise specified. T-test (one-tailed): ∗p ≤ 0.05, ∗∗p ≤ 0.001 compared to CU Aβ−.
Abbreviations: CU = cognitively unimpaired; MCI = mild cognitive impairment; AD = Alzheimer's disease dementia; APOE = apolipoprotein E gene; MMSE = Mini-Mental State Examination.
a
APOE genotype only available for 164/184 participants.