Table 2.

Baseline and annual tau SUVR change (cerebellar cortex reference region).

ROI	CU Aβ− (n = 89)		CU Aβ+ (n = 44)						MCI Aβ+ (n = 26)						AD Aβ+ (n = 25)
	Baseline SUVR	Δ SUVR/yr	Baseline SUVR	T stat	d	Δ SUVR/yr	T stat	d	Baseline SUVR	T stat	d	Δ SUVR/yr	T stat	d	Baseline SUVR	T stat	d	Δ SUVR/yr	T stat	d
Me	0.89 ± 0.16	0.0088 ± 0.0444	1.18 ± 0.29∗∗∗	6.33	1.34 [1.00–1.80]	0.0587 ± 0.0727∗∗∗	4.19	0.90 [0.52, 1.28]	1.53 ± 0.60∗∗∗	5.39	2.03 [1.51–2.53]	0.0169 ± 0.0884	0.45	0.14 [-0.30, 0.58]	1.90 ± 0.69∗∗∗	7.25	2.89 [2.30–3.46]	0.0313 ± 0.1885	0.59	0.24 [-0.21, 0.68]
MT	0.96 ± 0.14	0.0100 ± 0.0417	1.25 ± 0.29∗∗∗	6.20	1.41 [1.00–1.80]	0.0615 ± 0.0766∗∗∗	4.17	0.93 [0.55, 1.30]	1.70 ± 0.76∗∗∗	4.97	1.196 [1.45–2.46]	0.0393 ± 0.1068	1.37	0.47 [0.03, 0.91]	2.33 ± 0.86∗∗∗	7.94	3.28 [2.66–3.90]	0.0817 ± 0.2371	1.51	0.62 [0.17, 1.07]
Te	1.02 ± 0.13	0.0061 ± 0.0460	1.18 ± 0.24∗∗∗	4.16	0.92 [0.54–1.30]	0.0484 ± 0.0771∗∗∗	3.36	0.73 [0.36, 1.10]	1.62 ± 0.73∗∗∗	4.14	1.64 [1.15–2.12]	0.0523 ± 0.1111∗	2.07	0.70 [0.25, 1.14]	2.74 ± 1.36∗∗∗	6.34	2.70 [2.13–3.26]	0.1274 ± 0.2690∗	2.24	0.93 [0.46, 1.38]
R	0.88 ± 0.11	−0.0007 ± 0.0337	0.94 ± 0.14∗∗	2.44	0.45 [0.08–0.82]	0.0235 ± 0.0661∗	2.29	0.52 [0.15, 0.88]	1.21 ± 0.57∗∗	2.85	1.12 [0.66–1.58]	0.0365 ± 0.0911∗	2.04	0.71 [0.27, 1.16]	1.71 ± 0.91∗∗∗	4.53	1.91 [1.39–2.41]	0.1194 ± 0.1854∗∗	3.23	1.32 [0.84–1.80]

Baseline tau SUVR and annual tau SUVR change per year (Δ SUVR/year), normalised to the cerebellar cortex. T stat = t statistic from a one-tailed t-test comparing the Aβ+ clinical groups against the CU Aβ− group, ∗p ≤ 0.05, ∗∗p ≤ 0.01, ∗∗∗p ≤ 0.001. Effect size = Cohen's d, point estimate [95% confidence interval].

Abbreviations: Me = mesial temporal; MT = meta-temporal; Te = temporoparietal; R = rest of neocortex.