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. 2023 Jan 27;220(4):e20222173. doi: 10.1084/jem.20222173

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© 2023 Gurwicz et al.

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Figure 2. — Macrophage infiltration into LN follicles depends on GCs. (A) TPLSM images of popliteal LNs derived from CX3CR1^GFP mice that were adoptively transferred with TdTomato⁺ B1-8^hi B cells and imaged 3, 5, and 7 d after intra-footpad immunization with NP-OVA. Each time point was repeated twice, with two mice in each repeat. (B) Immunofluorescence staining of LN-derived from immunized and unimmunized mice. Each dot represents the density of macrophages in LN follicles; three to four mice were analyzed from each group. (C) Immunofluorescence staining of LNs derived from unimmunized and immunized SAP^KO mice. Each dot represents the density of macrophages in the follicles of three mice. Line represents the mean. *, P < 0.05; *, P < 0.01; ****, P < 0.0001; ns, not significant. Two-tailed Student’s t test in B, one-way ANOVA in C.