Table 3.
Focused Ultrasound for DIPG/DMG clinical trials.
| Title | NCT | Status | Location | Size | Device | Mechanism of Action | Drug |
|---|---|---|---|---|---|---|---|
| Non-Invasive Focused Ultrasound (FUS) in Children With Progressive Diffuse Midline Glioma (DMG) | NCT04804709 | On hold | New York, USA | 15 | Delsona | BBBO | Panobinostat |
| A Safety and Feasibility Study to Evaluate Blood-Brain Barrier Disruption Using Exablate MR-Guided Focused Ultrasound in Combination with Doxorubicin in Treating Pediatric Patients with Diffuse Intrinsic Pontine Gliomas |
NCT05630209 NCT05615623 |
Not yet recruiting | Washington DC, USA Toronto, Canada |
20 | InSightec | BBBO | Doxorubicin |
| A Phase I/II Study of Sonodynamic Therapy using SONALA-001 and ExAblate 4000 Type 2 in Patients with DMG | NCT05123534 | Recruiting | Phoenix, USA California, USA Washington DC, USA |
18 | InSightec | SDT | IV 5-ALA |