Figure 3.

Single and repeated administration of LNP-formulated C5-siRNA (SEQ008-34) lowers complement hemolytic activity in mice

(A and B) Mice (n = 4/group) received a single or repeated i.v. administration of either PBS or 0.3, 1, and 3 mg/kg of C5-siRNA/LNP. Blood samples were collected prior to and post administration (twice a week) and analyzed for complement hemolytic activity using a sheep RBC hemolysis assay. Hemolysis values were normalized to a “maximal hemolysis” control (lysis by water). Data are presented as mean ± SEM; q2w, every 2 week dosing.