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. 2023 Jan 26;25:95–106. doi: 10.1016/j.bioactmat.2023.01.015

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — Therapeutic effect of Au/CeO₂@HA in ulcerative colitis. (A) Overall protocol of the animal experiment. C57BL/6 mice received water or 3% DSS-containing water for 6 consecutive days. On the day 7, 9, and 11, mice were orally administered with Au/CeO₂@HA or CeO₂@HA (2 mg/kg) (n = 7). (B) Relative body weights of mice receiving treatments. (C) Colon lengths and (D) photos of colon tissues with indicated treatments on day 12. (E) Hematoxylin-eosin (H&E) staining images of colon tissues. (F) Relative myeloperoxidase (MPO) activity in colon homogenates. TNF-α levels in colon homogenates (G) and serum (H) of each group. IL-6 levels in colon homogenates (I, pg/mg protein) and serum (J, pg/mL) of each group. (K) IL-1β levels in colon homogenates of each group. Data represent mean ± SD (*p＜0.05, **p＜0.01, and ***p＜0.001).