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Effect of the ligands fgf1 and fgf2 on receptor activation.A, comparison of GRB2 contrast (CmScarlet) determined for the WT and mutant forms of FGFR3 in the absence and presence of fgf2. The p value annotation legend is ∗0.01 ≤ p ≤ 0.05; a full list can be found in Table S3. B, normalization of mean CmScarlet values to the nonactivated WT FGFR3. Data are shown as mean ± standard error. FGFR3, fibroblast growth factor receptor 3; GRB2, growth factor receptor–bound 2.
