Table 2:
Randomized trials of acute PD performed in ICU.
| Study | Ponce 2013 [69] | Gabriel 2008 [37] | Al-Hwiesh 2018 [38] | Ponce 2011 [52] | Parapiboon 2017 [53] |
|---|---|---|---|---|---|
| High volume PD vs daily EHD | High volume PD vs daily HD | Tidal APD vs CVVHDF | Higher vs lower intensity | Intensive vs minimal standard | |
| Number of patients | 63 vs 201 | 60 vs 60 | 63 vs 62 | 31 vs 30 | 41 vs 39 |
| Dosage | Weekly Kt/V 3.6 vs 4.1 | Weekly Kt/V 3.6 vs 4.7 | 25 L 70% tidal vs CVVHDF effluent 23 mL/kg/h | Weekly Kt/V 4.13 vs 3.0 | Weekly Kt/V 3.3 vs 2.26 |
| Ventilated | 83.6% vs 86.6% | 68% vs 75% | 62% vs 69% | 68% vs 72% | 87% vs 89% |
| APACHE II score | 27.5 vs 26.7 | 26.9 vs 24.1 | 22.1 vs 21.3 | 26.4 vs 24.8 | 26.9 vs 25.7 |
| Ultrafiltration (L) | 0.6 vs 1.4 | 2.1 vs 2.4 | 0.95 vs 1.39 | 2.4 vs 2.1 | 1.5 vs 0.5 (day 1), 2.1 vs 0.9 (day 2) |
| Mortality | 63.9% vs 63.4% (P = .94) | 58% vs 53% (P = .48) | 30.2 vs 53.2 (P = .002) | 55 vs 53% (P = .42) | 79% vs 63% (P = .13) |
| Limitations | Single centre, significantly different baseline characteristics | Single centre, patients not surviving 24 h excluded, underpowered for mortality | Single centre, adequate effluent rates on CKRT, however creatinine levels remained higher than expected for the dose achieved | Single centre | Single centre, small body surface area of patients |
EHD, extended haemodialysis; CVVHDF, continuous veno-veno haemodiafiltration.