Table 1.
Baseline characteristics (non-italic) and change in secondary outcome parameters from baseline to month 3
| Parameter | Unit | Non-responder (n = 3) | Responder (n = 5) |
|---|---|---|---|
| Age | years | 62 (13) | 61 (10) |
| Female | n | 3 | 3 |
| Body mass index | kg/m2 | 27 (7) | 29 (5) |
| Disease duration | years | 18 (10) | 10 (6) |
| Previous csDMARDs | n, median | 2 | 2 |
| Previous bDMARDs | n, median | 6 | 5.5 |
| DAS28ESR* | Mean (s.d.) | 5.7 (0.4) | 4.8 (0.3) |
| Total number of teeth | Median (IQR) | 20 (8, 21) | 14 (8, 16) |
| Number of pockets >4 mm | Median (IQR) | 15 (7, 17) | 14 (8, 15) |
| Probing depth | mm, median (IQR) | 3.1 (2.6, 3.4) | 3.9 (3.8, 3.9) |
| Change in probing depth | mm, median (IQR) | 1.0 (0.9–1.1) * | 1.4 (1.2–1.5), n = 4 |
| Clinical Attachment level (CAL)** | mm, median (IQR) | −3.5 (−5, −2.2) | −6.9 (−7, −6.6) |
| Change in CAL | mm, median (IQR) | 0.2 (0–1.1) * | 1.2 (0.9–1.4), n = 4 |
| BOP | Sites in %, median (IQR) | 27 (18, 83) | 40 (35, 46) |
| Change in BOP | Sites in %, median (IQR) | −19 (−48, −7) | −32 (−40, −20), n = 4 |
| O’Leary plaque index | Median (IQR) | 34 (16, 52) | 80 (0, 91) |
| A. actinomycetemcomitans | N | 0 | 0 |
| P. gingivalis | N | 1 | 1 |
| P. intermedia | N | 0 | 1 |
| Capnocytophaga sp.*** | N | 1 | 4 |
| RF | IU/ml | 420 (63, 777) | 157 (137, 561) |
| CCP antibodies | IU/ml | 169 (155, 183) | 190 (188, 191) |
| rVim | OD, median (IQR) | 0 (0, 0.008) | 0 (0, 0) |
| cVim | OD, median (IQR) | 0.026 (0.01, 1.344) | 0.078 (0.043, 0.098) |
| rFib | OD, median (IQR) | 0 (0, 0.038) | 0 (0, 0) |
| cFib | OD, median (IQR) | 0.286 (0.001, 0.694) | 0.158 (0.109, 0.674) |
| REP-1 | OD, median (IQR) | 0.008 (0.003, 0.012) | 0.004 (0.001, 0.006) |
| CEP-1 | OD, median (IQR) | 0.026 (0.01, 0.349) | 0.013 (0.013, 0.452) |
| rTNC5 | OD, median (IQR) | 0.061 (0.037, 0.063) | 0.038 (0.029, 0.041) |
| cTNC5** | OD, median (IQR) | 0.085 (0.074, 0.215) | 0.051 (0.037, 0.054) |
*P = 0.03,
**P = 0.05,
***P = 0.014.
Statistics for binary variables were Fisher’s exact text and for quantitative data Wilcoxon’s rank sum test. bDMARD: biological DMARD; BOP: bleeding on probing; CAL: clinical attachment level; csDMARD: conventional synthetic DMARD; cVim: antibodies against citrullinated vimentin peptides; IU: international unit; IQR: interquartile range; OD: optical density; REP-1 and CEP-1: antibodies against enolase and rTNC5 and cTNC5 against tenascin-C; rFib and cFib: antibodies against fibrinogen; rVim: antibodies against arginine baring.