Fig. 7.

Brain-targeted delivery of US-HA-Exo combined with FUS-mediated BBB opening. (A, B) Schematic of FUS-BBB opening-assisted delivery of exosomes. (C) Brain sections obtained from 10-month-old APP/PS1 mice were immuno-stained for Aβ, scale bar: 100 ​μm. (D) The percentage area of positive amyloid-β staining was quantified. (E, F) Aβ plaques in the brain were detected by thioflavin-S staining (E; scale bar: 100 ​μm), and quantified (F). (G) H&E staining of major organs of mice, scale bar: 100 ​μm. The image was reproduced from the article published in Theranostics Journal by Deng, Wang and Meng and Co-workers in the year 2021 [428]. Permission was obtained from the publisher for using the illustration.