Fig. 8.

Effect of ultrasound on distribution/accumulation of exosomes labeled with DiR. LIUS induced exosomes have similar in vivo distribution profile. (A) Schematic diagram of the experimental procedure. (B) Exosomes from cells treated with or without LIUS were labeled with DiR. About 100 ​μg (at protein level) of exosomes in 100 ​μL were injected to C57BL/6J mice via the tail vein. Ex vivo imaging was analyzed by IVIS and data were representative images of the data from three mice. (C) Statistical analysis of fluorescence intensity in whole mice, liver, spleen and lung. n ​= ​3. No significant differences were found. The image was reproduced from the article published in Journal of Drug Delivery Science and Technology by Zhao, Chen, Hao and Co-workers in the year 2020 [431]. Permission was obtained from the publisher for using the illustration.