Table 1.
Patient demographics and disease characteristics.
| Demographics and characteristics | Premenopausal | Postmenopausal | ||
|---|---|---|---|---|
| Abemaciclib + ET, n = 1227 | ET alone, n = 1224 | Abemaciclib + ET, n = 1576 | ET alone, n = 1605 | |
| Age, years (range) | ||||
| Median | 44 (23–65) | 44 (22–60) | 59 (32–89) | 59 (27–86) |
| Region, n (%) | ||||
| Asia | 340 (27.7) | 342 (27.9) | 234 (14.8) | 240 (15.0) |
| NA/EU | 596 (48.6) | 595 (48.6) | 870 (55.2) | 884 (55.1) |
| Other | 291 (23.7) | 287 (23.4) | 472 (29.9) | 481 (30.0) |
| Prior chemotherapy, n (%) | ||||
| Neoadjuvant | 512 (41.7) | 516 (42.2) | 510 (32.4) | 515 (32.1) |
| Adjuvant | 685 (55.8) | 675 (55.1) | 945 (60.0) | 958 (59.7) |
| No chemotherapy | 30 (2.4) | 33 (2.7) | 121 (7.7) | 132 (8.2) |
| Number of positive lymph nodes, n (%) | ||||
| 0 | 7 (0.6) | 1 (0.1) | 0 (0.0) | 6 (0.4) |
| 1 to 3 | 501 (40.8) | 520 (42.5) | 615 (39.0) | 622 (38.8) |
| ⩾4 or more | 719 (58.6) | 703 (57.4) | 961 (61.0) | 977 (60.9) |
| Histological grade, n (%) | ||||
| Grade 1 | 94 (7.7) | 91 (7.4) | 115 (7.3) | 125 (7.8) |
| Grade 2 | 585 (47.7) | 585 (47.8) | 790 (50.1) | 810 (50.5) |
| Grade 3 | 474 (38.6) | 467 (38.2) | 610 (38.7) | 597 (37.2) |
| Radiologic tumor size at diagnosis, n (%) | ||||
| <2 cm | 328 (26.7) | 330 (27.0) | 457 (29.0) | 449 (28.0) |
| 2–5 cm | 592 (48.2) | 599 (48.9) | 815 (51.7) | 860 (53.6) |
| ⩾5 cm | 262 (21.4) | 256 (20.9) | 239 (15.2) | 223 (13.9) |
| Pathologic tumor size at surgery, n (%) | ||||
| <2 cm | 351 (28.6) | 342 (27.9) | 430 (27.3) | 425 (26.5) |
| 2–5 cm | 571 (46.5) | 576 (47.1) | 798 (50.6) | 843 (52.5) |
| ⩾5 cm | 279 (22.7) | 288 (23.5) | 327 (20.7) | 322 (20.1) |
| Central Ki-67, n (%) | ||||
| <20% | 376 (30.6) | 395 (32.3) | 575 (36.5) | 579 (36.1) |
| ⩾20% | 576 (46.9) | 561 (45.8) | 684 (43.4) | 675 (42.1) |
| Unavailable | 275 (22.4) | 268 (21.9) | 317 (20.1) | 351 (21.9) |
Where values do not add up to 100%, remaining data are missing, unavailable, or could not be assessed.
ET, endocrine therapy; EU, Europe; NA, North America.