Figure 7.
PolyAMiner-Bulk analysis of bulk RNA-seq dataset of skin fibroblasts with and without siRNA-mediated knockdown of NUDT21. (A) Volcano plot of differential APA genes. (B) Upset plot analysis of PolyAMiner-Bulk results against previously published results. (C) NUDT21 motif and biding analysis on the unique 3’UTR shortening genes identified by PolyAMiner-Bulk. (D) Representative differential APA gene identified by PolyAMiner-Bulk but not the previously published study. (E) Representative differential APA gene identified by the previously published study but not PolyAMiner-Bulk. (F) Panther Pathway over representation analysis of the differential APA genes identified by PolyAMiner-Bulk. (G) GO:Biological Process over representation analysis of the differential APA genes identified by PolyAMiner-Bulk.